Effect of age and sex on warfarin dosing

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dc.contributor.author Khoury, Ghada
dc.contributor.author Sheikh-Taha, Marwan
dc.date.accessioned 2016-06-02T12:03:50Z
dc.date.available 2016-06-02T12:03:50Z
dc.date.copyright 2014 en_US
dc.date.issued 2016-06-02
dc.identifier.issn 1179-1438 en_US
dc.identifier.uri http://hdl.handle.net/10725/3934
dc.description.abstract Objective We examined the potential effect of sex and age on warfarin dosing in ambulatory adult patients. Methods We conducted a retrospective chart review of patients attending an anticoagulation clinic. We included patients anticoagulated with warfarin for atrial fibrillation or venous thromboembolism who had a therapeutic international normalized ratio of 2–3 for 2 consecutive months. We excluded patients who had been on any drug that is known to have a major interaction with warfarin, smokers, and heavy alcohol consumers. Out of 340 screened medical records, 96 met the predetermined inclusion criteria. The primary outcome assessed was warfarin total weekly dose (TWD). Results There was a statistically significant difference in the TWD among the ages (P<0.01); older patients required lower doses. However there was no statistically significant difference in the TWD between sexes (P=0.281). Conclusion Age was found to have a significant effect on warfarin dosing. Even though women did require a lower TWD than men, this observation was not statistically significant. en_US
dc.language.iso en en_US
dc.title Effect of age and sex on warfarin dosing en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 199410150 en_US
dc.author.idnumber 200104046
dc.author.department Pharmacy Practice Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Clinical Pharmacology: Advances and Applications en_US
dc.journal.volume 6 en_US
dc.article.pages 103-106 en_US
dc.keywords Warfarin en_US
dc.keywords INR en_US
dc.keywords Anticoagulation en_US
dc.keywords Vitamin K antagonist en_US
dc.keywords Age en_US
dc.identifier.doi http://dx.doi.org/10.2147/CPAA.S66776 en_US
dc.identifier.ctation Khoury, G., & Sheikh-Taha, M. (2014). Effect of age and sex on warfarin dosing. Clinical pharmacology: advances and applications, 6, 103. en_US
dc.author.email marwan.taha@lau.edu.lb en_US
dc.author.email ghada.khoury@lau.edu.lb
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103915/ en_US
dc.orcid.id https://orcid.org/0000-0002-7642-4833 en_US
dc.orcid.id https://orcid.org/0000-0002-8037-1201 en_US

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