Salvia libanotica improves glycemia and serum lipid profile in rats fed a high fat diet

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dc.contributor.author Bassil, Maya
dc.contributor.author Daher, Costantine F.
dc.contributor.author Mroueh, Mohammad
dc.contributor.author Zeeni, Nadine
dc.date.accessioned 2016-04-21T12:29:47Z
dc.date.available 2016-04-21T12:29:47Z
dc.date.copyright 2015
dc.date.issued 2016-04-21
dc.identifier.issn 1472-6882 en_US
dc.identifier.uri http://hdl.handle.net/10725/3629
dc.description.abstract Background Salvia libanotica (S. Libanotica) is a commonly used herb in folk medicine in Lebanon and the Middle East. The present study aimed to assess the scientific basis for the therapeutic use of S. libanotica in glycemia and to evaluate its effects on lipemia and abdominal fat. Methods Animals were fed a high-fat diet and allocated into a control and three experimental groups (GI, GII and GIII) receiving incremental doses of the plant water extract in drinking water (50, 150 and 450 mg/Kg body weight respectively) for six weeks. Results The intake of S. libanotica extract was associated with a significant decrease in fasting serum glucose (102.9 ± 10.8 in GII and 87.5 ± 6.4 in GIII vs. 152.1 ± 7.9 mg/dl in controls) and a two fold increase in fasting serum insulin (GIII) and liver glycogen content (GII and GIII). Group III also had better glucose tolerance following intraperitoneal glucose challenges. Additionally, the plant extract intake produced a significant improvement in serum HDL (34.4 ± 2.4 in GIII vs. 27.2 ± 1.9 mg/dl in controls) and HDL/LDL cholesterol ratio (2.79 ± 0.32 in GII and 3.02 ± 0.31 in GIII vs. 1.74 ± 0.18 in controls), as well as a decrease in abdominal fat. Conclusion The current study is the first to demonstrate that the chronic intake of S. libanotica infusion helps in the prevention of high fat-induced hyperglycemia and dyslipidemia. This supports the plant use as a remedy for the prevention of type 2 diabetes and cardiovascular diseases. en_US
dc.language.iso en en_US
dc.title Salvia libanotica improves glycemia and serum lipid profile in rats fed a high fat diet en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.school SOP
dc.author.idnumber 201102356 en_US
dc.author.idnumber 199190130
dc.author.idnumber 199590020
dc.author.idnumber 201000400
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal BMC Complementary and Alternative Medicine en_US
dc.journal.volume 15 en_US
dc.keywords Salvia libanotica en_US
dc.keywords Glycemia en_US
dc.keywords Blood glucose en_US
dc.keywords Blood lipid en_US
dc.keywords Blood cholesterol en_US
dc.identifier.doi http://dx.doi.org/ 10.1186/s12906-015-0917-8 en_US
dc.identifier.ctation Bassil, M., Daher, C. F., Mroueh, M., & Zeeni, N. (2015). Salvia libanotica improves glycemia and serum lipid profile in rats fed a high fat diet. BMC complementary and alternative medicine, 15(1) en_US
dc.author.email mbassil@lau.edu.lb
dc.author.email cdaher@lau.edu.lb
dc.author.email mmroueh@lau.edu.lb
dc.author.email nadine.zeeni@lau.edu.lb
dc.identifier.url http://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0917-8

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