Chemical and microbiological investigations of metal ion interaction with norfloxacin

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dc.contributor.author Na'was, T. E.
dc.contributor.author Alkaysi, H. N.
dc.contributor.author Abdel-Hay, M. H.
dc.contributor.author Sheikh Salem, M.
dc.contributor.author Gharaibeh, A. M.
dc.date.accessioned 2016-04-14T14:12:29Z
dc.date.available 2016-04-14T14:12:29Z
dc.date.copyright 1992
dc.identifier.issn 0378-5173 en_US
dc.identifier.uri http://hdl.handle.net/10725/3568
dc.description.abstract This report describes a spectrophotometric study on the interaction between norfloxacin (NFX) and metal ions (Al3+, Mg2+ and Ca2+). Two buffers of pH 3.6 and 8.8 were used. A shift in absorption maximum was observed and the stoichiometry of the complex was determined using the Job and molar methods. The ratios were NFX:AL3+, 2:1 and 3:1 for the NFX:Mg2+ complex. The formation of a complex with Al3+ enhanced the water solubility of the drug. Microbiological studies indicated decreased activity of norfloxacin in the presence of metal ions. en_US
dc.language.iso en en_US
dc.title Chemical and microbiological investigations of metal ion interaction with norfloxacin en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 198029370 en_US
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal International Journal of Pharmaceutics en_US
dc.journal.volume 87 en_US
dc.journal.issue 1-3 en_US
dc.article.pages 73-77 en_US
dc.keywords Norfloxacin en_US
dc.keywords Norfloxacin-metal ion interaction en_US
dc.keywords Antimicrobial activity en_US
dc.keywords Spectrophotometry en_US
dc.identifier.doi http://dx.doi.org/10.1016/0378-5173(92)90229-U en_US
dc.identifier.ctation Alkaysi, H. N., Abdel-Hay, M. H., Salem, M. S., Gharaibeh, A. M., & Na'was, T. E. (1992). Chemical and microbiological investigations of metal ion interaction with norfloxacin. International journal of pharmaceutics, 87(1), 73-77. en_US
dc.author.email tnawas@lau.edu.lb
dc.identifier.url http://www.sciencedirect.com/science/article/pii/037851739290229U

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