.

Chemical and microbiological investigations of metal ion interaction with norfloxacin

LAUR Repository

Show simple item record

dc.contributor.author Na'was, T. E.
dc.contributor.author Alkaysi, H. N.
dc.contributor.author Abdel-Hay, M. H.
dc.contributor.author Sheikh Salem, M.
dc.contributor.author Gharaibeh, A. M.
dc.date.accessioned 2016-04-14T14:12:29Z
dc.date.available 2016-04-14T14:12:29Z
dc.date.copyright 1992
dc.identifier.issn 0378-5173 en_US
dc.identifier.uri http://hdl.handle.net/10725/3568
dc.description.abstract This report describes a spectrophotometric study on the interaction between norfloxacin (NFX) and metal ions (Al3+, Mg2+ and Ca2+). Two buffers of pH 3.6 and 8.8 were used. A shift in absorption maximum was observed and the stoichiometry of the complex was determined using the Job and molar methods. The ratios were NFX:AL3+, 2:1 and 3:1 for the NFX:Mg2+ complex. The formation of a complex with Al3+ enhanced the water solubility of the drug. Microbiological studies indicated decreased activity of norfloxacin in the presence of metal ions. en_US
dc.language.iso en en_US
dc.title Chemical and microbiological investigations of metal ion interaction with norfloxacin en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 198029370 en_US
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal International Journal of Pharmaceutics en_US
dc.journal.volume 87 en_US
dc.journal.issue 1-3 en_US
dc.article.pages 73-77 en_US
dc.keywords Norfloxacin en_US
dc.keywords Norfloxacin-metal ion interaction en_US
dc.keywords Antimicrobial activity en_US
dc.keywords Spectrophotometry en_US
dc.identifier.doi http://dx.doi.org/10.1016/0378-5173(92)90229-U en_US
dc.identifier.ctation Alkaysi, H. N., Abdel-Hay, M. H., Salem, M. S., Gharaibeh, A. M., & Na'was, T. E. (1992). Chemical and microbiological investigations of metal ion interaction with norfloxacin. International journal of pharmaceutics, 87(1), 73-77. en_US
dc.author.email tnawas@lau.edu.lb
dc.identifier.url http://www.sciencedirect.com/science/article/pii/037851739290229U


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search LAUR


Advanced Search

Browse

My Account