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Phenotypic and Genotypic Characterization of Nosocomial Staphylococcus aureus Isolates from Trauma Patients

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dc.contributor.author Na'was, T.
dc.contributor.author Hawwari, A.
dc.contributor.author Hendrix, E.
dc.contributor.author Hebden, J.
dc.contributor.author Edelman, R.
dc.contributor.author Martin, M.
dc.contributor.author Campbell, W.
dc.contributor.author Naso, R.
dc.contributor.author Schwalbe, R.
dc.contributor.author Fttom, A.I.
dc.date.accessioned 2016-04-14T14:03:50Z
dc.date.available 2016-04-14T14:03:50Z
dc.date.copyright 1998
dc.identifier.issn 0095-1137 en_US
dc.identifier.uri http://hdl.handle.net/10725/3567
dc.description.abstract Staphylococcus aureus is a major cause of nosocomial infections. During the period from March 1992 to March 1994, the patients admitted to the intensive care unit of the University of Maryland Shock Trauma Center were monitored for the development ofS. aureus infections. Among the 776 patients eligible for the study, 60 (7.7%) patients developed 65 incidents of nosocomialS. aureus infections. Of the clinical isolates, 43.1% possessed a polysaccharide type 5 capsule, 44.6% possessed a type 8 capsule, and the remaining 12.3% had capsules that were not typed by the type 5 or type 8 antibodies. Six antibiogram types were noted among the infection-related isolates, with the majority of the types being resistant only to penicillin and ampicillin. It was noted that the majority of cases of pneumonia were caused by relatively susceptible strains, while resistant strains were isolated from patients with bacteremia and other infections. Only 16 (6.3%) of the isolates were found to be methicillin-resistant S. aureus (MRSA). DNA fingerprinting by pulsed-field gel electrophoresis showed 36 different patterns, with characteristic patterns being found for MRSA strains and the strains with different capsular types. Clonal relationships were established, and the origins of the infection-related isolates in each patient were determined. We conclude that (i) nosocomial infection-related isolates from the shock trauma patients did not belong to a single clone, although the predominance of a methicillin-resistant genotype was noted, (ii) most infection-relatedS. aureus isolates were relatively susceptible to antibiotics, but a MRSA strain was endemic, and (iii) for practical purposes, the combination of the results of capsular and antibiogram typing can be used as a useful epidemiological marker. en_US
dc.language.iso en en_US
dc.title Phenotypic and Genotypic Characterization of Nosocomial Staphylococcus aureus Isolates from Trauma Patients en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 198029370 en_US
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Clinical Microbiology en_US
dc.journal.volume 36 en_US
dc.journal.issue 2 en_US
dc.article.pages 414-420 en_US
dc.identifier.ctation Na’Was, T., Hawwari, A., Hendrix, E., Hebden, J., Edelman, R., Martin, M., ... & Fattom, A. I. (1998). Phenotypic and genotypic characterization of nosocomial Staphylococcus aureus isolates from trauma patients. Journal of clinical microbiology, 36(2), 414-420. en_US
dc.author.email tnawas@lau.edu.lb
dc.identifier.url http://jcm.asm.org/content/36/2/414.full


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