Abstract:
New derivatives of 2,3‐diarylglutamides were prepared in a one‐pot reaction by the hydrolysis of the corresponding diastereomeric pure (R,R) glutaronitriles using concentrated sulphuric acid at room temperature. The structure of the reaction products was established on the basis of their infrared, proton and carbon‐13 NMR spectroscopy as well as by their elemental analysis. The antibacterial activity of both diastereomeric pure glutaronitriles and glutaramides using four standard strains of bacteria is also described.
Citation:
Al‐Arab, M. M., Abu‐Yousef, I. A., & Na'Was, T. E. (1990). Stereoselective synthesis of new 2, 3‐diarylglutaramides and their antibacterial activity. Toxicological & Environmental Chemistry, 27(4) 277-284.