Synthesis and characterisation of metallopolyamide complexes

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dc.contributor.author Taleb, Robin
dc.contributor.author Orkey, Nikita
dc.contributor.author Aldrich-Wright, Janice
dc.date.accessioned 2016-04-06T06:08:00Z
dc.date.available 2016-04-06T06:08:00Z
dc.date.copyright 2012
dc.date.issued 2016-04-06
dc.identifier.issn 0020-1693 en_US
dc.identifier.uri http://hdl.handle.net/10725/3497
dc.description.abstract Platinum(II) and ruthenium(II)-based complexes that contain imidazole, pyrrole and β-alanine subunits, capable of recognising specific DNA base-pair sequences, have been synthesised. These polyamides, two platinum(II), [Cl(NH3)2Pt-L6-β-Ala-Py-L4-Im]+ (HSP-2), and [Cl(NH3)2Pt-L6-β-Ala-PyPyPy-L4-ImImIm]+ (HSP-6) and two ruthenium, Δ and Λ-[β-Ala-Py-L4-Im-β-dpq-Ru(phen)2]2+ (Δ and Λ-RUP1), were designed to recognise DNA sequences up to seven base-pairs in length. They were obtained in good yield by a combination of solid and solution phase chemistries. The chirality of the ruthenium precursors Δ- and Λ-[Ru(phen)2(phendo)]2+ was conserved throughout the synthesis. Characterisation was achieved using NMR, UV–Vis and ESI-MS and CD for Δ- and Λ-RUP1. Cytotoxicity was not determined for HSP-2 or HSP-6, due to insolubility, however the IC50 values of Δ and Λ-RUP1 were confirmed to be greater than 40 μM (at an incubation time of 48 h). LD studies indicated that the ruthenium complexes interact with ct-DNA through a mixed binding mode, which is influenced by complex concentration and chirality. en_US
dc.language.iso en en_US
dc.title Synthesis and characterisation of metallopolyamide complexes en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 200901968 en_US
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Inorganica Chimica Acta en_US
dc.journal.volume 393 en_US
dc.journal.issue 1 en_US
dc.article.pages 187-197 en_US
dc.keywords DNA recognition en_US
dc.keywords Platinum en_US
dc.keywords Ruthenium en_US
dc.keywords Polyamides en_US
dc.keywords Sequence selective en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.ica.2012.06.013 en_US
dc.identifier.ctation Orkey, N., Taleb, R. I., & Aldrich-Wright, J. R. (2012). Synthesis and characterisation of metallopolyamide complexes. Inorganica Chimica Acta, 393, 187-197. en_US
dc.author.email robin.taleb@lau.edu.lb
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0020169312003738

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