Synthesis of DNA-Sequence-Selective Hairpin Polyamide Platinum Complexes

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dc.contributor.author Taleb, Robin
dc.contributor.author Jaramillo, David
dc.contributor.author Wheate, Nial
dc.contributor.author Aldrich-Wright, Janice
dc.date.accessioned 2016-04-06T05:57:47Z
dc.date.available 2016-04-06T05:57:47Z
dc.date.copyright 2007
dc.date.issued 2016-04-06
dc.identifier.issn 0947-6539 en_US
dc.identifier.uri http://hdl.handle.net/10725/3496
dc.description.abstract Two DNA-sequence-selective hairpin polyamide platinum(II) complexes, containing pyrrole and imidazole heterocyclic rings, have been synthesised by different methods. A six-ring complex, selective for (A/T)GGG(A/T) DNA sequences, was made by using solid-phase synthesis, whilst an eight-ring complex, selective for (A/T)CCTG(A/T) DNA sequences, was made by utilising standard wet chemistry. Solid-phase synthesis resulted in a significantly higher yield, required less purification and is more efficient than the wet synthesis; as such, it is the preferred method for further work. The metal complexes were characterised by 1H and 195Pt NMR spectroscopy and ESI mass spectrometry. The two compounds provide a foundation for the synthesis of more complex molecules containing multiple hairpins and/or platinum groups. en_US
dc.language.iso en en_US
dc.title Synthesis of DNA-Sequence-Selective Hairpin Polyamide Platinum Complexes en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 200901968 en_US
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Chemistry a European Journal en_US
dc.journal.volume 13 en_US
dc.journal.issue 1 en_US
dc.article.pages 3177-3186 en_US
dc.keywords Antitumor agents en_US
dc.keywords DNA recognition en_US
dc.keywords Platinum en_US
dc.keywords Polyamides en_US
dc.keywords Synthesis design en_US
dc.identifier.doi http://dx.doi.org/10.1002/chem.200601486 en_US
dc.identifier.ctation Taleb, R. I., Jaramillo, D., Wheate, N. J., & Aldrich‐Wright, J. R. (2007). Synthesis of DNA‐Sequence‐Selective Hairpin Polyamide Platinum Complexes. Chemistry–A European Journal, 13(11), 3177-3186. en_US
dc.author.email robin.taleb@lau.edu.lb
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1002/chem.200601486/full

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