Community-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 80 Type IV (CC80- MRSA-IV) Isolated from the Middle East

LAUR Repository

Show simple item record

dc.contributor.author Tokajian, Sima T.
dc.contributor.author Harastani, Houda H.
dc.date.accessioned 2016-04-05T09:31:31Z
dc.date.available 2016-04-05T09:31:31Z
dc.date.copyright 2014
dc.date.issued 2016-04-05
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://hdl.handle.net/10725/3486
dc.description.abstract Background: The emergence of community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) has caused a change in MRSA epidemiology worldwide. In the Middle East, the persistent spread of CA-MRSA isolates that were associated with multilocus sequence type (MLST) clonal complex 80 and with staphylococcal cassette chromosome mec (SCCmec) type IV (CC80-MRSA-IV), calls for novel approaches for infection control that would limit its spread. Methodology/Principal Findings: In this study, the epidemiology of CC80-MRSA-IV was investigated in Jordan and Lebanon retrospectively covering the period from 2000 to 2011. Ninety-four S. aureus isolates, 63 (67%) collected from Lebanon and 31 (33%) collected from Jordan were included in this study. More than half of the isolates (56%) were associated with skin and soft tissue infections (SSTIs), and 73 (78%) were Panton-Valentine Leukocidin (PVL) positive. Majority of the isolates (84%) carried the gene for exofoliative toxin d (etd), 19% had the Toxic Shock Syndrome Toxin-1 gene (tst), and seven isolates from Jordan had a rare combination being positive for both tst and PVL genes. spa typing showed the prevalence of type t044 (85%) and pulsed-field gel electrophoresis (PFGE) recognized 21 different patterns. Antimicrobial susceptibility testing showed the prevalence (36%) of a unique resistant profile, which included resistance to streptomycin, kanamycin, and fusidic acid (SKF profile). Conclusions: The genetic diversity among the CC80 isolates observed in this study poses an additional challenge to infection control of CA-MRSA epidemics. CA-MRSA related to ST80 in the Middle East was distinguished in this study from the ones described in other countries. Genetic diversity observed, which may be due to mutations and differences in the antibiotic regimens between countries may have led to the development of heterogeneous strains. Hence, it is difficult to maintain ‘‘the European CA-MRSA clone’’ as a uniform clone and it is better to designate as CC80-MRSA-IV isolates. en_US
dc.language.iso en en_US
dc.title Community-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 80 Type IV (CC80- MRSA-IV) Isolated from the Middle East en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle A Heterogeneous Expanding Clonal Lineage en_US
dc.author.school SAS en_US
dc.author.idnumber 199736770 en_US
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal PLOS One en_US
dc.journal.volume 9 en_US
dc.journal.issue 7 en_US
dc.article.pages e103715 en_US
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0103715 en_US
dc.identifier.ctation Harastani, H. H., & Tokajian, S. T. (2014). Community-associated methicillin-resistant Staphylococcus aureus clonal complex 80 type IV (CC80-MRSA-IV) isolated from the Middle East: A heterogeneous expanding clonal lineage. PloS one, 9(7), e103715. en_US
dc.author.email stokjian@lau.edu.lb
dc.identifier.url http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103715
dc.orcid.id https://orcid.org/0000-0002-3653-8940

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search LAUR

Advanced Search


My Account