Natural Killer Cell Immunoglobulin-like Receptor (KIR) genotypes in Follicular Lymphoma patients

Abstract

Aims

The Natural Killer Cell Immunoglobulin-like Receptor (KIR) genotype profiling in Follicular Lymphoma has not been reported before in the literature.

Materials and methods

DNA extracted from 20 Follicular Lymphoma patients and 62 healthy controls was analyzed for KIR genotyping using a polymerase chain reaction/sequence specific primers technique (PCR/SSP) for the presence of 16 KIR gene and pseudogene loci.

Results

The AA, AB, and BB genotype frequencies were, respectively, 20%, 60% and 20% with an A:B ratio of 1:1. KIR 2DL4, KIR 3DL2, KIR 3DL3, and KIR 3DP1*003 were presented in all individuals. No significant difference between patients and controls was detected.

Conclusion

KIR genotyping profile does not seem to be associated with Follicular Lymphoma. The results presented in this pilot research represent the first international report about this important clinical entity.

Abbreviations KIR, Killer Cell Immunoglobulin-like Receptors; PCR, Polymerase chain reaction; SSP, Sequence specific primers; NHL, Non-Hodgkin's lymphoma; Ig, Immunoglobulin; FL, Follicular Lymphoma; NK, Natural killer; HLA, Human leukocyte antigens; MHC, Major histocompatibility complex; ITIM, Immunoreceptor tyrosine based inhibition motifs; HSTCL, Hepatosplenic T-cell lymphoma; UV, Ultraviolet