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dc.contributor.author Khazen, Georges
dc.contributor.author Ranjan, Rajnish
dc.contributor.author Gambazzi, Luca
dc.contributor.author Ramaswamy, Srikanth
dc.contributor.author Markram, Henry
dc.contributor.author Hill, Sean L.
dc.contributor.author Schürmann, Felix
dc.date.accessioned 2016-03-17T12:18:35Z
dc.date.available 2016-03-17T12:18:35Z
dc.date.copyright 2011
dc.date.issued 2016-03-17
dc.identifier.issn 1662-5196 en_US
dc.identifier.uri http://hdl.handle.net/10725/3355
dc.description.abstract Ion channels are membrane proteins that selectively conduct ions across the cell membrane. The flux of ions through ion channels drives electrical and biochemical processes in cells and plays a critical role in shaping the electrical properties of neurons. During the past three decades, extensive research has been carried out to characterize the molecular, structural, and biophysical properties of ion channels. This research has begun to elucidate the role of ion channels in neuronal function and has subsequently led to the development of computational models of ion channel function. Although there have been substantial efforts to consolidate these findings into easily accessible and coherent online resources, a single comprehensive resource is still lacking. The success of these initiatives has been hindered by the sheer diversity of approaches and the variety in data formats. Here, we present “Channelpedia” (http://channelpedia.net), which is designed to store information related to ion channels and models and is characterized by an efficient information management framework. Composed of a combination of a database and a wiki-like discussion platform Channelpedia allows researchers to collaborate and synthesize ion channel information from literature. Equipped to automatically update references, Channelpedia integrates and highlights recent publications with relevant information in the database. It is web based, freely accessible and currently contains 187 annotated ion channels with 45 Hodgkin–Huxley models. Keywords: ion channel, kinetics, Hodgkin–Huxley model, datab en_US
dc.language.iso en en_US
dc.title Channelpedia en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle An integrative and interactive database for ion channels en_US
dc.author.school SAS en_US
dc.author.idnumber 201105253 en_US
dc.author.woa N/A en_US
dc.author.department Computer Science and Mathematics en_US
dc.description.embargo N/A en_US
dc.relation.journal Frontiers in Neuroinformatics en_US
dc.journal.volume 5 en_US
dc.journal.issue 36 en_US
dc.article.pages 1-8 en_US
dc.keywords Ion channel en_US
dc.keywords Kinetics en_US
dc.keywords Hodgkin–Huxley model en_US
dc.keywords Database en_US
dc.keywords Information management en_US
dc.keywords Structured wiki en_US
dc.identifier.doi http://dx.doi.org/10.3389/fninf.2011.00036 en_US
dc.author.email GKhazen@lau.edu.lb
dc.identifier.url http://journal.frontiersin.org/article/10.3389/fninf.2011.00036/full

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