The effect of daucus carota pentane-diethylether fraction on cancer cells motility and metastasis. (c2013)

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dc.contributor.author Zgheib, Perla Z.
dc.date.accessioned 2016-03-07T07:11:13Z
dc.date.available 2016-03-07T07:11:13Z
dc.date.issued 2016-03-07
dc.date.submitted 2013-05-27
dc.identifier.uri http://hdl.handle.net/10725/3286
dc.description.abstract Daucus carota (DC) is a herb used in folklore medicine in Lebanon to treat numerous diseases and infections including cancer. Previous studies were done on the aqueous and methanolic plant extract in order to assess its anti-cancer, anti-oxidant and anti-inflammatory activities. Recent studies in our labs have focused on assessing the anti-cancer and anti-oxidant effects of the oil extract and its fractions on various types of cancers in vivo and in vitro. This study aims to investigate the effect of DCO pentane-diethylether fraction on lung, skin, breast and glioblastoma cancer motility and metastasis. This was done through 2D, 3D and molecular assays. Upon treatment, a pronounced decrease in cancer cell motility was observed in the four cell lines used. The treatment also led to a decrease in cancer cell invasion and an increased cell adhesion. In addition, a decrease in CDC42 activation levels, and an increase in Rac activation were detected. The significance of this study, which demonstrated a crucial effect of the pentane-diethylether fraction on cancer motility and metastasis, is towards reaching a potential cancer therapy specifically targeting cancer motility and metastasis. en_US
dc.language.iso en en_US
dc.subject Carrots -- Therapeutic use en_US
dc.subject Cells -- Motility en_US
dc.subject Metastasis en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.title The effect of daucus carota pentane-diethylether fraction on cancer cells motility and metastasis. (c2013) en_US
dc.type Thesis en_US
dc.term.submitted Spring en_US
dc.author.degree MS in Molecular Biology en_US
dc.author.school SAS en_US
dc.author.idnumber 200702111 en_US
dc.author.commembers Rizk, Sandra
dc.author.commembers Mroueh, Mohammad
dc.author.woa OA en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.description.physdesc 1 hard copy: xv, 50 leaves; ill.; 30 cm. available at RNL. en_US
dc.author.advisor El-Sibai, Mirvat
dc.author.advisor Daher, Costantine
dc.keywords Daucus Carota en_US
dc.keywords Cancer en_US
dc.keywords Metastasis en_US
dc.keywords Motility en_US
dc.keywords Rho-GTPases en_US
dc.description.bibliographiccitations Includes bibliographical references (leaves 45-50). en_US
dc.identifier.doi https://doi.org/10.26756/th.2013.52 en_US
dc.publisher.institution Lebanese American University en_US

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