Metformin inhibits 2D and 3D motility in astrocytoma cancer cells. (c2014)

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dc.contributor.author Hassan, Marwa Fouad Al
dc.date.accessioned 2016-03-03T13:32:28Z
dc.date.available 2016-03-03T13:32:28Z
dc.date.copyright 5/15/2014 en_US
dc.date.issued 2016-03-03
dc.identifier.uri http://hdl.handle.net/10725/3259
dc.description.abstract Metformin is an oral anti-hyperglycemic agent in the biguanide class which lowers blood glucose concentrations and has been used to treat type 2 diabetes mellitus. Metformin is highly used in polycystic ovary syndrome (PCOS), premature puberty, and non-alcoholic fatty liver disease (NAFLD). A brain tumor is an intracranial solid neoplasm which is a tumor within the brain or the central spinal canal. According to the World Health Organization (WHO), primary brain tumors are classified according to their histological characteristics and cellular origin. In addition, gliomas, which belong to the neuroepithelial brain tumors, include oligodendroglioma, astrocytoma, ependymoma, mixed glioma, and glioblastoma. Previous studies showed a cytotoxic effect of metformin on ovarian cells. This prompted us, in our current study, to investigate the effect of metformin on the proliferation and metastasis astrocytoma. When this drug is applied, it led to a relative decrease in the proliferation of astrocytoma cancer cells. Metformin treatment also resulted in a drastic inhibition of 2D cell motility and an increase in cellular adhesion. Hence, our study shows that Metformin could be used as an anti-metastatic drug in brain tumor. en_US
dc.language.iso en en_US
dc.subject Metformin -- Therapeutic use en_US
dc.subject Astrocytomas en_US
dc.subject Brain -- Tumors en_US
dc.subject Cells -- Motility en_US
dc.subject Cell proliferation -- Drug effects en_US
dc.subject Cell adhesion en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.title Metformin inhibits 2D and 3D motility in astrocytoma cancer cells. (c2014) en_US
dc.type Thesis en_US
dc.term.submitted Spring en_US
dc.author.degree MS in Molecular Biology en_US
dc.author.school SAS en_US
dc.author.idnumber 200702282 en_US
dc.author.commembers Jamati, Sandra Rizk
dc.author.commembers Khalaf, Roy
dc.author.woa OA en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.description.physdesc 1 hard copy: xiv, 33 leaves.; ill.; 30 cm. available at RNL. en_US
dc.author.advisor El-Sibai, Mirvat
dc.keywords Metformin en_US
dc.keywords Cell Proliferation en_US
dc.keywords Cell Adhesion en_US
dc.keywords Cell Motility en_US
dc.keywords Astrocytoma en_US
dc.description.bibliographiccitations Includes bibliographical references (leaves 25-33). en_US
dc.identifier.doi https://doi.org/10.26756/th.2014.63 en_US
dc.publisher.institution Lebanese American University en_US

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