DJ-1, a peten inhibitor, is a positive regulator of cancer cell motility. (c2014)

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dc.contributor.author Yassine, Rawan M.
dc.date.accessioned 2016-03-03T13:17:44Z
dc.date.available 2016-03-03T13:17:44Z
dc.date.copyright 5/16/2014 en_US
dc.date.issued 2016-03-03
dc.identifier.uri http://hdl.handle.net/10725/3258
dc.description.abstract DJ-1 is a 20-KDa protein that was first identified as an oncogene product responsible for a subset of familial Parkinson’s disease; hence its name PARK 7. Previous studies showed that DJ-1 negatively regulated the tumor suppressor gene PTEN expression; thus promoting the phosphorylation of the PI3K/Akt signaling pathway, and activating cell proliferation and transformation. Therefore, DJ-1 can be used as an indication of cancer metastasis and can be a potential therapeutic target. However, the localization, detailed mechanism and the role of DJ-1 in cellular motility are still not fully understood. Therefore, our study showed that DJ-1, at normal cellular condition, is present in the nucleus, mitochondria, golgi apparatus and plasma membrane of astrocytoma (SF268) cells. Upon its stimulation with EGF, DJ-1 localize outside the nucleus, leading to an increase in cellular motility in lung, brain, and breast cancer cells by activating the PI3K pathway. We also showed that this activation is carried out by inhibiting PTEN and thus regulating the RhoGTPases mainly Rac which is known to be involved in cellular motility. en_US
dc.language.iso en en_US
dc.subject Rho GTPases en_US
dc.subject Cells -- Motility en_US
dc.subject Antioncogenes en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.title DJ-1, a peten inhibitor, is a positive regulator of cancer cell motility. (c2014) en_US
dc.type Thesis en_US
dc.term.submitted Spring en_US
dc.author.degree MS in Molecular Biology en_US
dc.author.school SAS en_US
dc.author.idnumber 200703164 en_US
dc.author.commembers Khalaf, Roy
dc.author.commembers Abi-Habib, Ralph
dc.author.woa OA en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.description.physdesc 1 hard copy: xi, 55 leaves; ill.; 30 cm. available at RNL. en_US
dc.author.advisor El-Sibai, Mirvat
dc.author.advisor Rizk, Sandra
dc.keywords DJ-1 en_US
dc.keywords PTEN en_US
dc.keywords PI3K en_US
dc.keywords Cancer en_US
dc.keywords Motility en_US
dc.keywords Rho-GTPases en_US
dc.keywords Rac en_US
dc.description.bibliographiccitations Includes bibliographical references (leaves 43-55). en_US
dc.identifier.doi https://doi.org/10.26756/th.2014.62 en_US
dc.publisher.institution Lebanese American University en_US

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