Cdc42 relationship with palladin in invadopodia formation in astrocytoma. (c2014)

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dc.contributor.author Lakis, Emile A.
dc.date.accessioned 2016-03-03T11:01:48Z
dc.date.available 2016-03-03T11:01:48Z
dc.date.copyright 5/28/2014 en_US
dc.date.issued 2016-03-03
dc.identifier.uri http://hdl.handle.net/10725/3256
dc.description.abstract Astrocytomas, with their different grades, occur in young adulthood. Malignant astrocytomas are characterized by uncontrolled proliferation and a high invasiness profile to adjacent normal regions of the brain. The invasion of astrocytomas to nearby sites is mediated by the formation of invadopodia which is regulated mainly by Rho GTPases. Cdc42, a member of the Rho GTPases family, was shown to be involved in such process in many cell lines. We aimed first in determining the involvement of Cdc42 in 2D astrocytoma motility. Our results showed that 2D cell migration is Cdc42 independent. Our current study also investigated the role of Cdc42 in invadopodia formation in MTLn3 breast cancer cells and SF268 astrocytoma cells. Our results showed that Cdc42 in required for the formation of these structures. And finally, we elucidated signaling pathways between Cdc42, other Rho GTPases and Palladin in SF268 cells. Our findings revealed that RhoA upregulates Cdc42 activation levels, whereas RhoC and Palladin downregulate them. en_US
dc.language.iso en en_US
dc.subject Astrocytomas en_US
dc.subject Rho GTPases en_US
dc.subject Cell division en_US
dc.subject Cancer cells en_US
dc.subject Lebanese American University -- Dissertations en_US
dc.subject Dissertations, Academic en_US
dc.title Cdc42 relationship with palladin in invadopodia formation in astrocytoma. (c2014) en_US
dc.type Thesis en_US
dc.term.submitted Spring en_US
dc.author.degree MS in Molecular Biology en_US
dc.author.school SAS en_US
dc.author.idnumber 201103712 en_US
dc.author.commembers Daher, Constantine
dc.author.commembers Mroueh, Mohamad
dc.author.woa OA en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.description.physdesc 1 hard copy: xiii, 37 leaves; ill.; 30 cm. available at RNL. en_US
dc.author.advisor El - Sibai, Mirvat
dc.keywords Astrocytoma en_US
dc.keywords Rho GTPases en_US
dc.keywords Cdc42 en_US
dc.keywords Invadopodia en_US
dc.keywords Palladin en_US
dc.description.bibliographiccitations Includes bibliographical references (leaves 33-37). en_US
dc.identifier.doi https://doi.org/10.26756/th.2014.60 en_US
dc.publisher.institution Lebanese American University en_US

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