Abstract:
Dicarba cyclic peptide analogues of the cystine-containing octapeptides octreotide, lanreotide, and vapreotide, all known somatostatin analogues, have been synthesized via an on-resin homogeneous metal-catalysed sequence involving ruthenium-catalysed ring-closing metathesis followed by rhodium-catalysed hydrogenation.Key words: dicarba-analogues of cystine-containing peptides, octreotide, vapreotide, and lanreotide; tandem ring-closing metathesis and hydrogenation.
Citation:
Whelan, A. N., Elaridi, J., Mulder, R. J., Robinson, A. J., & Jackson, W. R. (2005). Metal-catalysed tandem metathesis-hydrogenation reactions for the synthesis of carba analogues of cyclic peptides. Canadian journal of chemistry, 83(6-7), 875-881.
