Abstract:
Enantioselective hydrogenation of a series of (E)-α-substituted β-amidoacrylates using Rh(I)-catalysts with chiral phosphine ligands (BPE, DuPHOS) gives β2-amino acid derivatives with enantioselectivities of up to 67%. A β2,3-amino acid derivative was also synthesised with similar enantioselectivity (⩽65%) from the corresponding prochiral enamide.
Citation:
Elaridi, J., Thaqi, A., Prosser, A., Jackson, W. R., & Robinson, A. J. (2005). An enantioselective synthesis of β< sup> 2</sup>-amino acid derivatives. Tetrahedron: Asymmetry, 16(7), 1309-1319.
