StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion

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dc.contributor.author Hanna, Samer
dc.contributor.author Khalil, Bassem
dc.contributor.author Nasrallah, Anita
dc.contributor.author Saykali, Bechara A.
dc.contributor.author Sobh, Rania
dc.contributor.author Nasser, Selim
dc.contributor.author El-Sibai, Mirvat
dc.date.accessioned 2015-12-18T07:30:44Z
dc.date.available 2015-12-18T07:30:44Z
dc.date.copyright 2014
dc.date.issued 2015-12-18
dc.identifier.issn 1019-6439 en_US
dc.identifier.uri http://hdl.handle.net/10725/2848
dc.description.abstract Breast cancer is one of the most commonly diagnosed cancers in women around the world. In general, the more aggressive the tumor, the more rapidly it grows and the more likely it metastasizes. Members of the Rho subfamily of small GTP-binding proteins (GTPases) play a central role in breast cancer cell motility and metastasis. The switch between active GTP-bound and inactive GDP-bound state is regulated by guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs) and guanine-nucleotide dissociation inhibitors (GDIs). We studied the role of StarD13, a recently identified Rho-GAP that specifically inhibits the function of RhoA and Cdc42. We aimed to investigate its role in breast cancer proliferation and metastasis. The levels of expression of this Rho-GAP in tumor tissues of different grades were assayed using immunohistochemistry. We observed that, while the level of StarD13 expression decreases in cancer tissues compared to normal tissues, it increases as the grade of the tumor increased. This was consistent with the fact that although StarD13 was indeed a tumor suppressor in our breast cancer cells, as seen by its effect on cell proliferation, it was needed for cancer cell motility. In fact, StarD13 knockdown resulted in an inhibition of cell motility and cells were not able to detach their tail and move forward. Our study describes, for the first time, a tumor suppressor that plays a positive role in cancer motility. en_US
dc.language.iso en en_US
dc.title StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.school SOM
dc.author.idnumber 200904866 en_US
dc.author.idnumber 200804624
dc.author.idnumber 200703859
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal International Journal of Oncology en_US
dc.journal.volume 44 en_US
dc.journal.issue 5 en_US
dc.article.pages 1791-2423 en_US
dc.keywords StarD13 en_US
dc.keywords RhoA en_US
dc.keywords Rac en_US
dc.keywords Breast cancer en_US
dc.keywords Cell motility en_US
dc.identifier.doi http://dx.doi.org/10.3892/ijo.2014.2330 en_US
dc.identifier.ctation Hanna, S., Khalil, B., Nasrallah, A., Saykali, B. A., Sobh, R., Nasser, S., & El-Sibai, M. (2014). StarD13 is a tumor suppressor in breast cancer that regulates cell motility and invasion. International journal of oncology, 44(5), 1499-1511. en_US
dc.author.email rania.sobh@lau.edu.lb
dc.author.email selim.nasser@lau.edu.lb
dc.author.email mirvat.elsibai@lau.edu.lb
dc.identifier.url https://www.spandidos-publications.com/ijo/44/5/1499
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US

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