Invadopodia, Regulation, and Assembly in Cancer Cell Invasion

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dc.contributor.author Saykali, Bechara A.
dc.contributor.author El-Sibai, Mirvat
dc.date.accessioned 2015-12-18T07:08:22Z
dc.date.available 2015-12-18T07:08:22Z
dc.date.copyright 2014
dc.date.issued 2015-12-18
dc.identifier.issn 1541-9061 en_US
dc.identifier.uri http://hdl.handle.net/10725/2845
dc.description.abstract The occurrence of invadopodia has been, since its characterization, a hallmark of cancerous cell invasion and metastasis. These structures are now the subject of a controversy concerning their cellular function, molecular regulation, and assembly. The terms invadopodia and podosomes have been used interchangeably since their discovery back in 1980. Since then, these phenotypes are now more established and accepted by the scientific community as vital structures for 3D cancer cell motility. Many characteristics relating to invadopodia and podosomes have been elucidated, which might prove these structures as good targets for metastasis treatment. In this review, we briefly review the actin reorganization process needed in most types of cancer cell motility. We also review the important characteristics of invadopodia, including molecular components, assembly, markers, and the signaling pathways, providing a comprehensive model for invadopodia regulation. en_US
dc.language.iso en en_US
dc.title Invadopodia, Regulation, and Assembly in Cancer Cell Invasion en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 200703859
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Cell Communication & Adhesion en_US
dc.journal.volume 21 en_US
dc.journal.issue 4 en_US
dc.article.pages 207-212 en_US
dc.keywords Invadopodia en_US
dc.keywords Podosome en_US
dc.keywords 3D motility en_US
dc.keywords Cancer motility en_US
dc.keywords Signaling en_US
dc.identifier.doi http://dx.doi.org/10.3109/15419061.2014.923845 en_US
dc.identifier.ctation Saykali, B. A., & El-Sibai, M. (2014). Invadopodia, regulation, and assembly in cancer cell invasion. Cell communication & adhesion, 21(4), 207-212. en_US
dc.author.email mirvat.elsibai@lau.edu.lb
dc.identifier.url http://www.tandfonline.com/doi/abs/10.3109/15419061.2014.923845
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US

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