Palladin regulation of the actin structures needed for cancer invasion

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dc.contributor.author Najm, Paul
dc.contributor.author El-Sibai, Mirvat
dc.date.accessioned 2015-12-17T13:31:14Z
dc.date.available 2015-12-17T13:31:14Z
dc.date.copyright 2014
dc.date.issued 2015-12-17
dc.identifier.issn 1933-6918 en_US
dc.identifier.uri http://hdl.handle.net/10725/2826
dc.description.abstract Cell migration and invasion involve the formation of cell adhesion structures as well as the dynamic and spatial regulation of the cytoskeleton. The adhesive structures known as podosomes and invadopodia share a common role in cell motility, adhesion, and invasion, and form when the plasma membrane of motile cells undergoes highly regulated protrusions. Palladin, a molecular scaffold, co-localizes with actin-rich structures where it plays a role in their assembly and maintenance in a wide variety of cell lines. Palladin regulates actin cytoskeleton organization as well as cell adhesion formation. Moreover, palladin contributes to the invasive nature of cancer metastatic cells by regulating invadopodia formation. Palladin seems to regulate podosome and invodopodia formation through Rho GTPases, which are known as key players in coordinating the cellular responses required for cell migration and metastasis. en_US
dc.language.iso en en_US
dc.title Palladin regulation of the actin structures needed for cancer invasion en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 200703859 en_US
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Cell Adhesion & Migration en_US
dc.journal.volume 8 en_US
dc.journal.issue 1 en_US
dc.article.pages 29-35 en_US
dc.keywords Palladin en_US
dc.keywords Actin en_US
dc.keywords Invasion en_US
dc.keywords Invadopodia en_US
dc.keywords Podosome en_US
dc.identifier.doi http://dx.doi.org/10.4161/cam.28024 en_US
dc.identifier.ctation Najm, P., & El-Sibai, M. (2014). Palladin regulation of the actin structures needed for cancer invasion. Cell adhesion & migration, 8(1), 29-35. en_US
dc.author.email mirvat.elsibai@lau.edu.lb
dc.identifier.url http://www.tandfonline.com/doi/abs/10.4161/cam.28024#.V5r5hLh97cs
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US

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