The STAR of the DLC family

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dc.contributor.author El-Sitt, Sally
dc.contributor.author El-Sibai, Mirvat
dc.date.accessioned 2015-12-17T13:10:53Z
dc.date.available 2015-12-17T13:10:53Z
dc.date.copyright 2013
dc.date.issued 2015-12-17
dc.identifier.issn 1079-9893 en_US
dc.identifier.uri http://hdl.handle.net/10725/2824
dc.description.abstract RhoGTPases are defined as a family of 20 small G proteins playing important roles in almost every cellular process. RhoGTPases are guanine nucleotide-binding proteins existing in two forms: the active form which is GTP bound and the inactive one that being GDP bound. RhoGTPase-activating proteins known as RhoGAPs constitute one of the major classes of regulators of RhoGTPases. They act as negative regulators of the RhoGTPases by enhancing their slow intrinsic GTPase activity. STARD13, a GTPase activating protein (GAP) for RhoGTPases, has been described as a tumor suppressor in hepatocellular carcinoma. In the present review, we discuss the family of RhoGTPases, their regulation and their RhoGAPs, focusing mainly on STARD13. en_US
dc.language.iso en en_US
dc.title The STAR of the DLC family en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 200703859 en_US
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Receptors and Signal Transduction en_US
dc.journal.volume 33 en_US
dc.journal.issue 1 en_US
dc.article.pages 10-13 en_US
dc.keywords DLC1 en_US
dc.keywords DLC2 en_US
dc.keywords DLC3 en_US
dc.keywords GAPs en_US
dc.keywords Tumor suppressor en_US
dc.identifier.doi http://dx.doi.org/10.3109/10799893.2012.752002 en_US
dc.identifier.ctation El-Sitt, S., & El-Sibai, M. (2013). The STAR of the DLC family. Journal of Receptors and Signal Transduction, 33(1), 10-13. en_US
dc.author.email mirvat.elsibai@lau.edu.lb
dc.identifier.url http://www.tandfonline.com/doi/abs/10.3109/10799893.2012.752002
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US

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