ALOX5AP gene variants show differential association with coronary artery disease in different populations

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dc.contributor.author Alwan, Ahmad
dc.contributor.author Youhanna, Sonia C.
dc.contributor.author Platt, Daniel E.
dc.contributor.author El-Sibai, Mirvat
dc.contributor.author Yerezian, Joumana S.
dc.contributor.author Deeb, Mary E.
dc.contributor.author Khazen, Georges
dc.contributor.author Saade, Stephanie
dc.contributor.author Zreik, Tony G.
dc.contributor.author El Bayeh, Hamid
dc.contributor.author Maalouf, Assaad
dc.contributor.author Zalloua, Pierre A.
dc.contributor.author Abchee, Antoine en_US
dc.date.accessioned 2015-12-17T13:05:01Z
dc.date.available 2015-12-17T13:05:01Z
dc.date.copyright 2010
dc.date.issued 2015-12-17
dc.identifier.issn 1868-310X en_US
dc.identifier.uri http://hdl.handle.net/10725/2823
dc.description.abstract Coronary artery disease (CAD) is a complex disease with various components, genetic as well as environmental. Previous reports correlating ALOX5AP gene variants and CAD showed conflicting results depending on the population studied. In this study, we examined the contribution of ALOX5AP genetic predisposition to CAD in a group of CAD patients and controls carefully selected from the Lebanese population. We genotyped SNPs for ALOX5AP variants in 289 catheterized patients aged ≤52 years with >50% stenosis in at least one main coronary artery and 227 catheterized control subjects aged 60 years and above with 0% stenosis. Chi-square (χ 2) tests and logistic regression showed no significant difference in the allele and genotype frequencies between the CAD or myocardial infarction (MI) cases and the healthy controls. Haplotype analysis using PHASE showed that the distribution of the risk haplotypes among cases and controls were not significantly different and had no attributable risk to CAD (P = 1.00 and P = 0.5, respectively) or MI (P = 0.2 and P = 0.5, respectively). Our data revealed that ALOX5AP gene variants are not predictors of CAD risk or MI risk among Lebanese patients. en_US
dc.language.iso en en_US
dc.title ALOX5AP gene variants show differential association with coronary artery disease in different populations en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.school SOP
dc.author.school SOM
dc.author.idnumber 200703859 en_US
dc.author.idnumber 200900035
dc.author.idnumber 201105253
dc.author.idnumber 200802707
dc.author.idnumber 200902679
dc.author.idnumber 200300001
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Community Genetics en_US
dc.journal.volume 1 en_US
dc.journal.issue 3 en_US
dc.article.pages 107-115 en_US
dc.keywords CAD en_US
dc.keywords Stenosis en_US
dc.keywords ALOX5AP en_US
dc.keywords SNP en_US
dc.keywords Inflammation en_US
dc.identifier.doi http://dx.doi.org/10.1007/s12687-010-0015-z en_US
dc.identifier.ctation Alwan, A., Youhanna, S. C., Platt, D. E., El-Sibai, M., Yerezian, J. S., Deeb, M. E., ... & Maalouf, A. (2010). ALOX5AP gene variants show differential association with coronary artery disease in different populations. Journal of community genetics, 1(3), 107-115. en_US
dc.author.email mirvat.elsibai@lau.edu.lb
dc.author.email mary.deeb@lau.edu.lb
dc.author.email GKhazen@lau.edu.lb
dc.author.email tgzreik@lau.edu.lb
dc.author.email hamid.elbayeh@lau.edu.lb
dc.author.email pierre.zalloua@lau.edu.lb
dc.identifier.url http://link.springer.com/article/10.1007/s12687-010-0015-z
dc.orcid.id https://orcid.org/0000-0002-8494-5081
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US

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