The I allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease

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dc.contributor.author Abchee, Antoine
dc.contributor.author El-Sibai, Mirvat
dc.contributor.author Youhanna, Sonia
dc.contributor.author Yeretzian, Joumana S.
dc.contributor.author Hanine, Estephan
dc.contributor.author Makhoul, Nadine J.
dc.contributor.author Puzantian, Houry
dc.contributor.author Sawaya, Jaber
dc.contributor.author Nasrallah, Antoine
dc.contributor.author Rebeiz, Abdallah G.
dc.contributor.author Zreik, Tony G.
dc.contributor.author Azar, Sami T.
dc.contributor.author Zalloua, Pierre A.
dc.date.accessioned 2015-12-17T11:59:18Z
dc.date.available 2015-12-17T11:59:18Z
dc.date.copyright 2010
dc.date.issued 2017-07-27
dc.identifier.issn 0954-6928 en_US
dc.identifier.uri http://hdl.handle.net/10725/2821
dc.description.abstract Background: Mutations in genes regulating lipid metabolism, vasoactivity, and coagulation are important modulators of coronary artery disease (CAD). Objective: This study investigated the association between allelic variants of the angiotensin converting enzyme (ACE), methytetrahydrofolate reductase, plasminogen activator inhibitor-1 and factor V genes and CAD. Methods: Clinical, biochemical, and angiographic information were collected from 300 patients who underwent cardiac catheterization and their DNA was genotyped by restriction fragment length polymorphism. Results: The frequency of the D allele of the ACE gene was significantly higher than the I allele in patients with more than 70% stenosis in any vessel. Among patients with more than 70% stenosis, carriers of the D allele were 2.8 times more likely to be males. The presence of the ACE I allele was negatively associated with CAD with (P=0.02 ,OR=0.38.) Conclusion: This study describes a protective role of the ACE I allele in individuals who may be at risk of developing CAD. en_US
dc.language.iso en en_US
dc.title The I allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 200703859 en_US
dc.author.idnumber 200802707
dc.author.idnumber 200300001
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Coronary Artery Disease en_US
dc.journal.volume 21 en_US
dc.journal.issue 3 en_US
dc.article.pages 151-156 en_US
dc.identifier.doi http://dx.doi.org/10.1097/MCA.0b013e328335a042 en_US
dc.identifier.ctation Abchee, A., El-Sibai, M., Youhanna, S., Yeretzian, J. S., Estephan, H., Makhoul, N. J., ... & Zreik, T. G. (2010). The I allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease. Coronary artery disease, 21(3), 151-156. en_US
dc.author.email mirvat.elsibai@lau.edu.lb
dc.author.email tgzreik@lau.edu.lb
dc.author.email pierre.zalloua@lau.edu.lb
dc.identifier.url http://journals.lww.com/coronary-artery/Abstract/2010/05000/The_I_allele_of_the_angiotensin_converting_enzyme.4.aspx en_US
dc.orcid.id https://orcid.org/0000-0002-8494-5081
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US

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