Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex

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dc.contributor.author Mroueh, Mohamad
dc.contributor.author Daher, Costantine
dc.contributor.author Hariri, Essa
dc.contributor.author Demirdjian, Sally
dc.contributor.author Isber, Samih
dc.contributor.author Choi, Eun Sang
dc.contributor.author Mirtamizdoust, Babak
dc.contributor.author Hammud, Hassan H.
dc.date.accessioned 2015-12-16T07:43:29Z
dc.date.available 2015-12-16T07:43:29Z
dc.date.copyright 2015
dc.date.issued 2015-12-16
dc.identifier.issn 0009-2797 en_US
dc.identifier.uri http://hdl.handle.net/10725/2814
dc.description.abstract The dinuclear complex bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] (1) was synthesized, and characterized by X-ray, FTIR and thermal analysis. The fitting of magnetic susceptibility and magnetization curve of (1) indicates the occurrence of weak antiferromagnetic exchange interaction between copper(II) ions. The electronic structure has been also determined by density functional theory (DFT) method. Complex (1) displayed potent anticancer activity against B16 (Melanoma), MDA-MB-32 (Breast Adenocarcinoma), A549 (Lung Adenocarcinoma), HT-29 (Colon Adenocarcinoma) and SF (Astrocytoma) cell lines with an average IC50 value of 0.726 μg/ml compared to 4.88 μg/ml for cisplatin. Complex (1) has a better therapeutic index and toxicological profile than cisplatin, and has demonstrated a potential chemotherapeutic property. en_US
dc.language.iso en en_US
dc.title Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.school SOP
dc.author.idnumber 199190130 en_US
dc.author.idnumber 199590020
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Chemico-Biological Interactions en_US
dc.journal.volume 231 en_US
dc.article.pages 53-60 en_US
dc.keywords Copper(II) phenanthroline en_US
dc.keywords Magnetism en_US
dc.keywords Thermal en_US
dc.keywords DFT en_US
dc.keywords In vitro cytotoxicity en_US
dc.keywords Anticancer en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.cbi.2015.02.023 en_US
dc.identifier.ctation Mroueh, M., Daher, C., Hariri, E., Demirdjian, S., Isber, S., Choi, E. S., ... & Hammud, H. H. (2015). Magnetic property, DFT calculation, and biological activity of bis [(μ 2-chloro) chloro (1, 10-phenanthroline) copper (II)] complex. Chemico-biological interactions, 231, 53-60. en_US
dc.author.email mmroueh@lau.edu.lb
dc.author.email cdaher@lau.edu.lb
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0009279715000927

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