Effect of acute and chronic grapefruit, orange, and pineapple juice intake on blood lipid profile in normolipidemic rat.

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dc.contributor.author Daher, Costantine F.
dc.contributor.author Abou-Khalil, Jamil
dc.contributor.author Baroody, George
dc.date.accessioned 2015-12-15T10:30:07Z
dc.date.available 2015-12-15T10:30:07Z
dc.date.copyright 2005
dc.date.issued 2015-12-15
dc.identifier.issn 1234-1010 en_US
dc.identifier.uri http://hdl.handle.net/10725/2807
dc.description.abstract Background: High fruit intake is known to be associated with reduced riskof coronary heart disease. Our objective was to determine the effects of acute and chronic juice [grapefruit,orange, and pineapple] intake on plasma lipid profile and lipoprotein metabolism in normolipidemic rats.Material/Methods: The effects of acute juice intake were studied after three hours of a single juice-lipidload instilled intragastrically. In the chronic study, blood samples from fasted animals were subjectedto analyses after six months of either water [control] or water-juice [1:1] intake. Results: In the acutestudy, pineapple and grapefruit significantly decreased plasma triacylglycerol [TAG], and chylomicron[CM] TAG and cholesterol concentrations concomitantly with delayed gastric emptying. Plasma cholesterollevels and very-low-density lipoprotein [VLDL] secretion and metabolism were not affected. In the chronicstudy, only grapefruit significantly decreased plasma and VLDL TAG concentrations and relative VLDL particlesize with respect to other groups. All juices significantly increased VLDL apolipoprotein B [apoB] secretion,but plasma total apoB concentrations were highest in the grapefruit group and lowest in the orange andpineapple groups. No effect on blood cholesterol levels was observed. Conclusions: The cardioprotectivebenefit of chronic juice intake in normolipidemic rat may be chiefly through mechanisms independent ofa direct effect on blood lipid profile, although orange and pineapple, but not grapefruit, relativelyimproved the metabolism and clearance of blood lipoprotein particles. As a result of delayed gastricemptying, grapefruit and pineapple juices may moderate sharp increases in postprandial plasma TAG concentrationsaccompanying peak digestion and absorption. en_US
dc.language.iso en en_US
dc.title Effect of acute and chronic grapefruit, orange, and pineapple juice intake on blood lipid profile in normolipidemic rat. en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 199190130 en_US
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Medical Science Monitor en_US
dc.journal.volume 11 en_US
dc.journal.issue 12 en_US
dc.article.pages BR465-472 en_US
dc.keywords Beverages en_US
dc.keywords Rats en_US
dc.keywords Male en_US
dc.keywords Lipids - blood en_US
dc.keywords Drinking en_US
dc.keywords Citrus sinensis - chemistry en_US
dc.keywords Citrus paradisi - chemistry en_US
dc.keywords Ananas - chemistry en_US
dc.keywords Animals en_US
dc.keywords Sprague-Dawley en_US
dc.identifier.ctation Daher, C., Abou-Khalil, J., & Baroody, G. (2005). Effect of acute and chronic grapefruit, orange, and pineapple juice intake on blood lipid profile in normolipidemic rat. Medical science monitor, 11(12), BR465-BR472. en_US
dc.author.email cdaher@lau.edu.lb
dc.identifier.url http://www.medscimonit.com/download/index/idArt/438850

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