Leishmania major

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dc.contributor.author Daher, Costantine F.
dc.contributor.author Baroody, George M.
dc.contributor.author Karam, Marc C.
dc.contributor.author Haber, Marc E.
dc.date.accessioned 2015-12-15T10:20:53Z
dc.date.available 2015-12-15T10:20:53Z
dc.date.copyright 2009
dc.date.issued 2015-12-15
dc.identifier.issn 0014-4894 en_US
dc.identifier.uri http://hdl.handle.net/10725/2806
dc.description.abstract Interleukin-13 (IL-13) is a powerful anti-inflammatory cytokine that was previously shown to be a susceptibility factor for Leishmania major (L. major) infection. In this study we report a different role for IL-13 in rats infected with L. major; rIL-13 stimulates expression of pro-inflammatory cytokines and IL-12 which is a key cytokine in protective immunity against Leishmania. Infected rats received daily injections of rIL-13 for eight consecutive days which resulted in increased pain perception for the first week post-infection assessed by thermal pain tests. This hyperalgesia was accompanied by a sustained early up-regulation of interleukin-1β followed by an up-regulation of IL-12p70. Real-time PCR showed no negative impact for rIL-13 upon the clearance of the parasites from the infection sites and blood. en_US
dc.language.iso en en_US
dc.title Leishmania major en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle Interleukin-13 increases the infection-induced hyperalgesia and the levels of interleukin-1β and interleukin-12 in rats en_US
dc.author.school SAS en_US
dc.author.idnumber 199190130 en_US
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Experimental Parasitology en_US
dc.journal.volume 121 en_US
dc.journal.issue 3 en_US
dc.article.pages 224-229 en_US
dc.keywords Leishmania major en_US
dc.keywords Hyperalgesia en_US
dc.keywords Interleukin-13 en_US
dc.keywords Pain tests en_US
dc.keywords Immunoassays en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.exppara.2008.11.004 en_US
dc.identifier.ctation Haber, M. E., Daher, C. F., Karam, M. C., & Baroody, G. M. (2009). Leishmania major: Interleukin-13 increases the infection-induced hyperalgesia and the levels of interleukin-1β and interleukin-12 in rats. Experimental parasitology, 121(3), 224-229. en_US
dc.author.email cdaher@lau.edu.lb
dc.identifier.url http://www.ncbi.nlm.nih.gov/pubmed/19061890

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