Acute Effect of Leptin and Ghrelin Injection on Postprandial Glycogen and Lipid Synthesis in Rats

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dc.contributor.author Bassil, Maya S.
dc.contributor.author Mrayati, Maha M.
dc.contributor.author Hwalla, Nahla C.
dc.contributor.author Obeid, Omar A.
dc.date.accessioned 2015-12-04T09:44:43Z
dc.date.available 2015-12-04T09:44:43Z
dc.date.issued 2015-12-04
dc.identifier.issn 0250-6807 en_US
dc.identifier.uri http://hdl.handle.net/10725/2759
dc.description.abstract Aim: The study was designed to investigate the immediate (1 h) effect of leptin and ghrelin injection on in vivo postprandial hepatic glycogen and lipid synthesis. Animals andMethods: Adult Sprague-Dawley male rats were fed a semisynthetic control diet ad libitum. Overnight-fasted rats were gavaged with 4 ml of water containing 1.25 g of the diet and immediately injected intraperitoneally with 4 mCi of 3H2O. After 1 h, rats were either intraperitoneally injected with saline (control), leptin (20 µg/rat) or ghrelin (10 µg/rat) and sacrificed 1 h later. Blood, liver and epididymal fat pads (EFP) were taken for analysis. Results: Plasma triglyceride level was higher in the leptin group compared to control. Leptin injection reduced hepatic glycogen synthesis while glycogen accumulation was not affected and ghrelin injection did not affect hepatic glycogen synthesis. Both hepatic and EFP lipogenesis were not affected by leptin or ghrelin. Conclusion: Leptin and ghrelin administration had no immediate effect on hepatic and adipose tissue lipogenesis. Leptin reduced in vivo postprandial hepatic glycogenesis and increased plasma triglyceride level which may be due to reduced uptake by peripheral tissues. Thus, leptin was found to exert an immediate effect on lipid and carbohydrate metabolism unlike that of ghrelin. en_US
dc.language.iso en en_US
dc.title Acute Effect of Leptin and Ghrelin Injection on Postprandial Glycogen and Lipid Synthesis in Rats en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201102356 en_US
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Annals of nutrition & metabolism en_US
dc.journal.volume 51 en_US
dc.journal.issue 1 en_US
dc.article.pages 14-21 en_US
dc.keywords Liver en_US
dc.keywords Insulin en_US
dc.keywords Glucose en_US
dc.keywords Trygleceride en_US
dc.keywords Metabolism en_US
dc.identifier.doi http://dx.doi.org/10.1159/000100816 en_US
dc.identifier.ctation Bassil, M. S., Mrayati, M. M., Hwalla, N. C., & Obeid, O. A. (2007). Acute effect of leptin and ghrelin injection on postprandial glycogen and lipid synthesis in rats. Annals of Nutrition and Metabolism, 51(1), 14-21. en_US
dc.author.email mbassil@lau.edu.lb
dc.identifier.url http://www.karger.com/Article/Abstract/100816

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