Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon

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dc.contributor.author Mroueh, Mohamad
dc.contributor.author Daher, Costantine F.
dc.contributor.author Hage-Sleiman, Rouba
dc.date.accessioned 2015-12-01T08:30:52Z
dc.date.available 2015-12-01T08:30:52Z
dc.date.copyright 2011-02-01
dc.date.issued 2015-12-01
dc.identifier.issn 1388-0209 en_US
dc.identifier.uri http://hdl.handle.net/10725/2743
dc.description.abstract Context: Althaea officinalis Linn. (Malvaideae) flower is commonly used in folk medicine in Lebanon and neighboring countries. Although most of the studies have been conducted on the mucilage-rich roots, little is known about the flower. Objective: This study investigates the potential role of aqueous extract of Althaea officinalis flower in lipemia, gastric ulcer, inflammation, and platelet aggregation using the rat model. Material and Methods: Blood lipid profile and liver function were assessed after 1 month of extract intake via drinking water. Anti-inflammatory activity was tested against acute and chronic inflammation induced by carrageenan and formalin, respectively. Antiulcer activity was evaluated using ethanol-induced gastric ulcer. Antiplatelet activity was investigated in vitro using the adenosine 5′-diphosphate (ADP)-induced platelet aggregation bioassay. Results: The 50 mg/kg body weight dose resulted in significant increase in serum HDL cholesterol level with no effects on stool cholesterol and triacylglycerol. Increasing the dose to 500 mg/kg body weight caused a significant decrease in stool water content. No adverse effect on liver enzymes was observed. Significant anti-inflammatory (acute and chronic inflammation) and antiulcerogenic activities were observed at all used doses (50, 100, and 250 mg/kg body). Time-dependent inhibition of platelet aggregation was demonstrated at 500 µg/ml concentration. Discussion and conclusion: The aqueous extract of Althaea officinalis flower demonstrated potential benefits in lipemia, inflammation, gastric ulcer, and platelet aggregation with no visible adverse effect. en_US
dc.language.iso en en_US
dc.title Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.school SAS
dc.author.idnumber 199590020 en_US
dc.author.idnumber 199190130
dc.author.woa N/A en_US
dc.author.department Pharmaceutical Sciences Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Pharmaceutical Biology en_US
dc.journal.volume 49 en_US
dc.journal.issue 3 en_US
dc.article.pages 327-333 en_US
dc.keywords Althaea officinalis en_US
dc.keywords Anti-inflammatory en_US
dc.keywords Antiulcerogenic en_US
dc.keywords HDL-cholesterol en_US
dc.identifier.doi http://dx.doi.org/10.3109/13880209.2010.516754
dc.identifier.ctation Hage-Sleiman, R., Mroueh, M., & Daher, C. F. (2011). Pharmacological evaluation of aqueous extract of Althaea officinalis flower grown in Lebanon. Pharmaceutical biology, 49(3), 327-333. en_US
dc.author.email mmroueh@lau.edu.lb
dc.author.email cdaher@lau.edu.lb
dc.identifier.url http://www.tandfonline.com/doi/abs/10.3109/13880209.2010.516754
dc.orcid.id https://orcid.org/0000-0002-8275-7263

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