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dc.contributor.author Kaseb, A.O.
dc.contributor.author Abbruzzese, J.L.
dc.contributor.author Vauthey, J.-N.
dc.contributor.author Aloia, T.A.
dc.contributor.author Abdalla, Eddie
dc.contributor.author Hassan, M.M.
dc.contributor.author Xiao, L.
dc.contributor.author Lin, E.
dc.contributor.author Rashid, A.
dc.contributor.author Morris, J.S.
dc.date.accessioned 2015-11-19T13:53:10Z
dc.date.available 2015-11-19T13:53:10Z
dc.date.copyright 2011
dc.date.issued 2015-11-19
dc.identifier.issn 0030-2414 en_US
dc.identifier.uri http://hdl.handle.net/10725/2634
dc.description.abstract Objective: Improving the prognostic stratification of unresectable hepatocellular carcinoma (HCC) patients is critically needed. Since patients’ survival is closely linked to the severity of the underlying liver disease, and insulin-like growth factor-1 (IGF-1) is produced predominantly in the liver, we hypothesized that IGF-1 may correlate with patients’ survival and hence improve the prognostic ability of the Cancer of the Liver Italian Program (CLIP) score. Methods: Baseline plasma IGF-1 and clinicopathologic parameters were available from 288 patients. Multivariate Cox regression models, Kaplan-Meier curves, and the log-rank test were applied. Recursive partitioning was used to determine the optimal cut point for IGF-1 using training/validation samples. Prognostic ability of the I-CLIP (I = IGF) was compared to CLIP using C-index. Results: IGF-1 significantly correlated with the clinicopathologic features. With an optimal IGF-1 cut point of 26 ng/ml, the overall survival of patients with IGF-1 >26 was 17.7 months (95% CI 13.6–22.8), and with IGF-1 ≤26 was 5.8 months (95% CI 4.0–12.5), p < 0.0001. The concordance probabilities for CLIP and I-CLIP were 0.7037 and 0.7096, respectively (p < 0.0001). Conclusions: Our preliminary results indicate that I-CLIP significantly improved prognostic stratification of patients with advanced HCC. However, independent validation of our study is warranted. en_US
dc.language.iso en en_US
dc.title I-CLIP en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle Improved Stratification of Advanced Hepatocellular Carcinoma Patients by Integrating Plasma IGF-1 into CLIP Score en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Oncology en_US
dc.journal.volume 80 en_US
dc.journal.issue 5-6 en_US
dc.article.pages 373-381 en_US
dc.keywords Cancer of liver italian program (CLIP) score en_US
dc.keywords Chronic liver disease en_US
dc.keywords Hepatocellular carcinoma en_US
dc.keywords IGF-1 en_US
dc.identifier.doi http://dx.doi.org/10.1159/000329040 en_US
dc.identifier.ctation Kaseb, A. O., Abbruzzese, J. L., Vauthey, J. N., Aloia, T. A., Abdalla, E. K., Hassan, M. M., ... & Morris, J. S. (2011). I-CLIP: improved stratification of advanced hepatocellular carcinoma patients by integrating plasma IGF-1 into CLIP score. Oncology, 80(5-6), 373-381. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://www.karger.com/Article/Fulltext/329040

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