Improved Survival after Resection of Liver and Lung Colorectal Metastases Compared with Liver-Only Metastases

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dc.contributor.author Brouquet, Antoine
dc.contributor.author Vauthey, Jean-Nicolas
dc.contributor.author Contreras, Carlo
dc.contributor.author Walsh, Garett
dc.contributor.author Vaporciyan, Ara
dc.contributor.author Swisher, Stephen
dc.contributor.author Curley, Steven
dc.contributor.author Mehran, Reza
dc.contributor.author Abdalla, Eddie
dc.date.accessioned 2015-11-19T12:08:29Z
dc.date.available 2015-11-19T12:08:29Z
dc.date.copyright 2011
dc.date.issued 2017-04-11
dc.identifier.issn 1072-7515 en_US
dc.identifier.uri http://hdl.handle.net/10725/2631
dc.description.abstract Background Lung metastases are considered a poor prognostic factor in patients with resectable colorectal liver metastases. Study Design We reviewed records of 1,260 consecutive patients with liver-only or liver-plus-lung (L+L) metastases from colorectal cancer who underwent resection with curative intent (1995 to 2009). Survival and prognostic factors were analyzed. Results There were 112 patients who underwent resection of L+L (mean 2 liver, 2 lung metastases). Mean tumor sizes were 3 cm and 1 cm, respectively. Thirty-four (31%) had bilateral lung metastases. Ten (9%) had synchronous L+L metastases, 60 (54%) had diagnosis of lung metastases within 1 year of liver resection. Most (108 of 112, 96%) had resection of liver before or at the same time as lung. Preoperative chemotherapy was used in 77 (69%) before liver resection and 56 (50%) before lung resection. Among L+L patients, no postoperative deaths occurred; postoperative morbidity rates were 26% after liver resection and 4% after lung resection. After a median of 49 months follow-up, L+L patients (n = 112) had better survival than liver only (n = 1,148) (5-year overall survival, L+L, 50% vs liver only, 40%; p = 0.01). CEA level > 5 ng/dL (hazard ratio [HR] 2.1, 95% CI 1.1 to 4.4, p = 0.04) and rectal primary (HR 2.9, 95% CI 1.4 to 6, p = 0.004) were associated with worse survival in L+L patients. Conclusions The survival rate for patients who undergo resection of L+L metastases from colorectal cancer is greater than the survival rate of the general population of patients who undergo resection of liver metastases only. The presence of resectable lung metastases is neither a poor prognostic factor nor a contraindication to resection of liver metastases. en_US
dc.language.iso en en_US
dc.title Improved Survival after Resection of Liver and Lung Colorectal Metastases Compared with Liver-Only Metastases en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle A Study of 112 Patients with Limited Lung Metastatic Disease en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of the American College of Surgeons en_US
dc.journal.volume 213 en_US
dc.journal.issue 1 en_US
dc.article.pages 62-69 en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.jamcollsurg.2011.05.001 en_US
dc.identifier.ctation Brouquet, A., Vauthey, J. N., Contreras, C. M., Walsh, G. L., Vaporciyan, A. A., Swisher, S. G., ... & Abdalla, E. K. (2011). Improved survival after resection of liver and lung colorectal metastases compared with liver-only metastases: a study of 112 patients with limited lung metastatic disease. Journal of the American College of Surgeons, 213(1), 62-69. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S1072751511003383

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