Hepatectomy for recurrent colorectal liver metastases after radiofrequency ablation

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dc.contributor.author Brouquet, A.
dc.contributor.author Vauthey, J.-N.
dc.contributor.author Loyer, E.M.
dc.contributor.author Kaur, H.
dc.contributor.author Curley, S.
dc.contributor.author Abdalla, Eddie
dc.date.accessioned 2015-11-19T10:01:00Z
dc.date.available 2015-11-19T10:01:00Z
dc.date.copyright 2011
dc.date.issued 2017-04-26
dc.identifier.issn 0007-1323 en_US
dc.identifier.uri http://hdl.handle.net/10725/2629
dc.description.abstract Background: The results of surgery for recurrent colorectal liver metastases (CLM) after radiofrequency ablation (RFA) have not been evaluated. Methods: From 1993 to 2009, data on patients who underwent resection or RFA for recurrent CLM were collected prospectively. Inclusion criteria for this study were RFA as initial treatment for CLM and resection of recurrent CLM after RFA. Postoperative results and oncological outcomes were analysed. Results: Twenty-eight patients (median number of tumours 1 (1–3), median size 2·8 (2·0–4·0) cm) met the inclusion criteria. Of these, 22 had recurrence at the site of RFA only, two developed new lesions, whereas four had both recurrent and de novo metastases. At the time of resection, patients had a median of 1 (1–13) CLM with a median maximum tumour diameter of 5·0 (1·8–11·0) cm, significantly larger than at the time of RFA (P = 0·021). Ninety-day postoperative morbidity and mortality rates were 46 per cent (13 of 28) and 7 per cent (2 of 28) respectively. After a median follow-up of 35 (0–70) months, 3-year overall and disease-free survival rates calculated by Kaplan–Meier analysis were 60 and 29 per cent respectively. Plasma carcinoembryonic antigen level over 5 ng/ml at the time of resection and a rectal primary tumour were associated with worse survival (P = 0·041 and P = 0·021 respectively). Conclusion: Resection for recurrence after RFA is associated with significant morbidity and modest long-term benefit. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. en_US
dc.language.iso en en_US
dc.title Hepatectomy for recurrent colorectal liver metastases after radiofrequency ablation en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal British Journal of Surgery en_US
dc.journal.volume 98 en_US
dc.journal.issue 7 en_US
dc.article.pages 1003-1009 en_US
dc.identifier.doi http://dx.doi.org/10.1002/bjs.7506 en_US
dc.identifier.ctation Brouquet, A., Vauthey, J. N., Badgwell, B. D., Loyer, E. M., Kaur, H., Curley, S. A., & Abdalla, E. K. (2011). Hepatectomy for recurrent colorectal liver metastases after radiofrequency ablation. British Journal of Surgery, 98(7), 1003-1009. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1002/bjs.7506/full

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