Association between hypothyroidism and hepatocellular carcinoma

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dc.contributor.author Hassan, Manal
dc.contributor.author Kaseb, Ahmed
dc.contributor.author Li, Donghui
dc.contributor.author Vauthey, Jean-Nicolas
dc.contributor.author Thomas, Melanie
dc.contributor.author Curley, Steven
dc.contributor.author Spitz, Margaret
dc.contributor.author Sherman, Steven
dc.contributor.author Abdalla, Eddie
dc.contributor.author Davila, Marta
dc.contributor.author Lozano, Richard
dc.contributor.author Hassan, Deena
dc.contributor.author Wenyaw, Chan
dc.contributor.author Brown, Thomas
dc.contributor.author Abbruzzese, James
dc.contributor.author Patt, Yehuda
dc.date.accessioned 2015-11-17T12:19:03Z
dc.date.available 2015-11-17T12:19:03Z
dc.date.copyright 2008
dc.date.issued 2015-11-17
dc.identifier.issn 0270-9139 en_US
dc.identifier.uri http://hdl.handle.net/10725/2599
dc.description.abstract Thyroid hormones play an essential role in lipid mobilization, lipid degradation, and fatty acid oxidation. Hypothyroidism has been associated with nonalcoholic steatohepatitis; however, the association between thyroid diseases and hepatocellular carcinoma (HCC) in men and women has not been well established. We investigated the association between hypothyroidism and HCC risk in men and women in a case-control study, which included 420 eligible patients with HCC and 1104 healthy controls. We used multivariate unconditional logistic regression models to control for the confounding effects of established HCC risk factors. A long-term history of hypothyroidism (>10 years) was associated with a statistically significant high risk of HCC in women; after adjusting for demographic factors, diabetes, hepatitis, alcohol consumption, cigarette smoking, and family history of cancer, the odds ratio (OR) was 2.9 (95% confidence interval [CI], 1.3-6.3). Restricted analyses among hepatitis virus–negative subjects, nondrinkers, nondiabetics, nonsmokers, and nonobese individuals indicated a significant association between hypothyroidism and HCC, with an approximate two-fold to three-fold increased risk of HCC development. We observed risk modification among women with diabetes mellitus (OR = 9.4; 95% CI = 2.7-32.7) and chronic hepatitis virus infection (OR = 31.2; 95% CI = 6.3-153.2). A history of hyperthyroidism was not significantly related to HCC (OR = 1.7; CI = 0.6-5.1). We noted significant elevated risk association between hypothyroidism and HCC in women that was independent of established HCC risk factors. Experimental investigations are necessary for thorough assessment of the relationship between thyroid disorders and HCC. (HEPATOLOGY 2009;49:1563–1570.) en_US
dc.language.iso en en_US
dc.title Association between hypothyroidism and hepatocellular carcinoma en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle A case-control study in the United States en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Hepatology en_US
dc.journal.volume 49 en_US
dc.journal.issue 5 en_US
dc.article.pages 1563-1570 en_US
dc.identifier.doi http://dx.doi.org/10.1002/hep.22793 en_US
dc.identifier.ctation Hassan, M. M., Kaseb, A., Li, D., Patt, Y. Z., Vauthey, J. N., Thomas, M. B., ... & Abbruzzese, J. L. (2009). Association between hypothyroidism and hepatocellular carcinoma: A case‐control study in the United States. Hepatology, 49(5), 1563-1570. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1002/hep.22793/full

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