Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women

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dc.contributor.author Hassan, Manal
dc.contributor.author Spitz, Margaret
dc.contributor.author Thomas, Melanie
dc.contributor.author El-Deeb, Adel
dc.contributor.author Glover, Katrina
dc.contributor.author Nguyem, Nga
dc.contributor.author Chan, Wenyaw
dc.contributor.author Kaseb, Ahmed
dc.contributor.author Curley, Steven
dc.contributor.author Vauthey, Nicolas
dc.contributor.author Ellis, Lee
dc.contributor.author Abdalla, Eddie
dc.contributor.author Lozano, Richard
dc.contributor.author Patt, Yehuda
dc.contributor.author Brown, Thomas
dc.contributor.author Abbruzzese, James
dc.contributor.author Li, Donghui
dc.date.accessioned 2015-11-17T07:23:19Z
dc.date.available 2015-11-17T07:23:19Z
dc.date.copyright 2008
dc.date.issued 2015-11-17
dc.identifier.issn 0020-7136 en_US
dc.identifier.uri http://hdl.handle.net/10725/2588
dc.description.abstract The International Agency for Research on Cancer has declared smoking to be a risk factor for hepatocellular carcinoma (HCC). However, passive exposure to cigarette smoke and use of noncigarette tobacco products on the risk of HCC has not been examined. Therefore, we evaluated the independent effects of different types of smoking exposure along with multiple risk factors for HCC and determined whether the magnitude of smoking was modified by other risk factors in men and women. We conducted a case-control study at The University of Texas M. D. Anderson Cancer Center where 319 HCC patients and 1,061 healthy control subjects were personally interviewed for several HCC risk factors. Multivariate logistic regression analysis was performed to estimate the adjusted odds ratio (AOR) and 95% confidence interval (CI) for each potential risk factor. Use of smokeless tobacco (chewing tobacco and snuff), cigars, pipes and passive smoking exposure were not related to HCC among noncigarette smokers. However, regular cigarette smoking was associated with HCC in men: AOR, 1.9 (95% CI, 1.1–3.1). Heavy alcohol consumption was associated with HCC in women: AOR, 7.7 (95% CI, 2.3–25.1). Cigarette smoking interacted synergistically with chronic infection of hepatitis C virus in men: AOR, 136.3 (95% CI, 43.2–429.6) and with heavy alcohol consumption in women: AOR, 13.7 (95% CI, 3.2–57.9). We conclude that sex differences were observed in HCC relationship with cigarette smoking and alcohol consumption. Controlling for smoking exposure might be a prudent approach to the prevention of HCC, especially in patients with chronic viral hepatitis infections. © 2008 Wiley-Liss, Inc. en_US
dc.language.iso en en_US
dc.title Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle Case-control study en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal International Journal of Cancer en_US
dc.journal.volume 123 en_US
dc.journal.issue 8 en_US
dc.article.pages 1883-1891 en_US
dc.keywords Passive smoking en_US
dc.keywords HCC en_US
dc.keywords Cigarette smoking en_US
dc.keywords Gender en_US
dc.keywords Pipes en_US
dc.keywords Cigars en_US
dc.keywords Tobacco en_US
dc.identifier.doi http://dx.doi.org/10.1002/ijc.23730 en_US
dc.identifier.ctation Hassan, M. M., Spitz, M. R., Thomas, M. B., El‐Deeb, A. S., Glover, K. Y., Nguyen, N. T., ... & Li, D. (2008). Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: Case‐control study. International Journal of Cancer, 123(8), 1883-1891. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1002/ijc.23730/full

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