Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases

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dc.contributor.author Zorzi, D.
dc.contributor.author Laurent, A.
dc.contributor.author Pawlik, T.M.
dc.contributor.author Lauwers, G.Y.
dc.contributor.author Vauthey, J.-N.
dc.contributor.author Abdalla, Eddie
dc.date.accessioned 2015-11-16T11:48:05Z
dc.date.available 2015-11-16T11:48:05Z
dc.date.copyright 2007
dc.date.issued 2015-11-16
dc.identifier.issn 0007-1323 en_US
dc.identifier.uri http://hdl.handle.net/10725/2581
dc.description.abstract Background: Preoperative systemic chemotherapy is increasingly used in patients who undergo hepatic resection for colorectal liver metastases (CLM). Although chemotherapy-related hepatic injury has been reported, the incidence and the effect of such injury on patient outcome remain ill defined. Methods: A systematic review of relevant studies published before May 2006 was performed. Studies that reported on liver injury associated with preoperative chemotherapy for CLM were identified and data on chemotherapy-specific liver injury and patient outcome following hepatic resection were synthesized and tabulated. Results: Hepatic steatosis, a mild manifestation of non-alcoholic fatty liver disease (NAFLD), may occur after treatment with 5-fluorouracil and is associated with increased postoperative morbidity. Nonalcoholic steatohepatitis, a serious complication of NAFLD that includes inflammation and hepatocyte damage, can occur after treatment with irinotecan, especially in obese patients. Irinotecan-associated steatohepatitis can affect hepatic reserve and increase morbidity and mortality after hepatectomy. Hepatic sinusoidal obstruction syndrome can occur in patients treated with oxaliplatin, but does not appear to be associated with an increased risk of perioperative death. Conclusion: Preoperative chemotherapy for CLM induces regimen-specific hepatic changes that can affect patient outcome. Both response rate and toxicity should be considered when selecting preoperative chemotherapy in patients with CLM. en_US
dc.language.iso en en_US
dc.title Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal British Journal of Surgery en_US
dc.journal.volume 94 en_US
dc.journal.issue 3 en_US
dc.article.pages 274-286 en_US
dc.identifier.doi http://dx.doi.org/10.1002/bjs.5719 en_US
dc.identifier.ctation Zorzi, D., Laurent, A., Pawlik, T. M., Lauwers, G. Y., Vauthey, J. N., & Abdalla, E. K. (2007). Chemotherapy‐associated hepatotoxicity and surgery for colorectal liver metastases. British Journal of Surgery, 94(3), 274-286. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1002/bjs.5719/full

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