Outcomes of Liver Transplantation in 490 Patients with Hepatocellular Carcinoma

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dc.contributor.author Vauthey, Nicolas
dc.contributor.author Ribero, Dario
dc.contributor.author Abdalla, Eddie
dc.contributor.author Jonas, Sven
dc.contributor.author Bharat, Ankit
dc.contributor.author Schumacher, Guido
dc.contributor.author Lerut, Jan
dc.contributor.author Chapman, William
dc.contributor.author Hemming, Alan
dc.contributor.author Neuhaus, Peter
dc.date.accessioned 2015-11-16T11:38:26Z
dc.date.available 2015-11-16T11:38:26Z
dc.date.copyright 2007
dc.date.issued 2015-11-16
dc.identifier.issn 1072-7515 en_US
dc.identifier.uri http://hdl.handle.net/10725/2580
dc.description.abstract Background The aim of this study was to compare the ability of staging systems (American Joint Committee on Cancer/Union Internationale contre le Cancer [AJCC/UICC], Japanese TNM, Pittsburgh, United Network for Organ Sharing [UNOS], Cancer of the Liver Italian Program [CLIP], Japan Integrated Staging [JIS], and Barcelona Clinic Liver Cancer [BCLC]) to predict survival after liver transplantation for hepatocellular carcinoma. Study Design Four hundred ninety consecutive patients who underwent liver transplantation for hepatocellular carcinoma at 4 centers (1985 to 2005) were identified using a registry (US, Belgium, Germany). End points were overall (OS) and recurrence-free survival (RFS). Survival by stage was compared with the log-rank test. Sequential stage-wise discrimination of each system was evaluated using Cox regression. Results Three- and 5-year overall survival rates were 71% and 64%, respectively; recurrence-free survival rates were 67% and 61%, respectively. Median followup among 327 living and 308 recurrence-free patients was 40 months. In only three systems—AJCC/UICC, Japanese TNM, and Pittsburgh—were overall and recurrence-free survivals longer for patients with low stage versus more advanced stage. For overall and recurrence-free survivals, sequential stages were different only for AJCC/UICC. In the Japanese TNM system, stages II and I were similar; for Pittsburgh, grades 3 and 2 were similar. For the United Network for Organ Sharing system, stages II and I and stages IVA1 and III were similar. All stages were similar for the Cancer of the Liver Italian Program. For the Japan Integrated Staging, scores 2 and 1 and scores 4 and 3 were similar. In the Barcelona Clinic Liver Cancer, stage D patients had significantly better survival than patients at stage C. Conclusions The AJCC/UICC staging system provides the best stratification of prognosis for patients undergoing liver transplantation for hepatocellular carcinoma. This confirms previous analyses in patients treated with hepatic resection. The AJCC/UICC staging system should be considered for uniform prediction of outcomes after surgery for hepatocellular carcinoma. en_US
dc.language.iso en en_US
dc.title Outcomes of Liver Transplantation in 490 Patients with Hepatocellular Carcinoma en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle Validation of a Uniform Staging after Surgical Treatment en_US
dc.author.school SOM en_US
dc.author.idnumber 20110945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of the American College of Surgeons en_US
dc.journal.volume 204 en_US
dc.journal.issue 5 en_US
dc.article.pages 1016-1027 en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.jamcollsurg.2006.12.043 en_US
dc.identifier.ctation Vauthey, J. N., Ribero, D., Abdalla, E. K., Jonas, S., Bharat, A., Schumacher, G., ... & Neuhaus, P. (2007). Outcomes of liver transplantation in 490 patients with hepatocellular carcinoma: validation of a uniform staging after surgical treatment. Journal of the American College of Surgeons, 204(5), 1016-1027. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S1072751507000890

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