Simultaneous Resections of Colorectal Cancer and Synchronous Liver Metastases

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dc.contributor.author Reddy, Srinevas
dc.contributor.author Pawlik, Timothy
dc.contributor.author Zorzi, Daria
dc.contributor.author Gleisner, Ana
dc.contributor.author Ribero, Dario
dc.contributor.author Assumpc ao, Lia
dc.contributor.author Barbas, Andrew
dc.contributor.author Abdalla, Eddie
dc.contributor.author Choti, Micheal
dc.contributor.author Vauthey, Nicolas
dc.contributor.author Ludwig, Krik
dc.contributor.author Mantyh, Christopher
dc.contributor.author Morse, Micheal
dc.contributor.author Clary, Bryan
dc.date.accessioned 2015-11-16T09:51:57Z
dc.date.available 2015-11-16T09:51:57Z
dc.date.copyright 2007
dc.date.issued 2015-11-16
dc.identifier.issn 1068-9265 en_US
dc.identifier.uri http://hdl.handle.net/10725/2576
dc.description.abstract Background The safety of simultaneous resections of colorectal cancer and synchronous liver metastases (SCRLM) is not established. This multi-institutional retrospective study compared postoperative outcomes after simultaneous and staged colorectal and hepatic resections. Methods Clinicopathologic data, treatments, and postoperative outcomes from patients who underwent simultaneous or staged colorectal and hepatic resections at three hepatobiliary centers from 1985–2006 were reviewed. Results 610 patients underwent simultaneous (n = 135) or staged (n = 475) resections of colorectal cancer and SCRLM. Seventy staged patients underwent colorectal and hepatic resections at the same institution. Simultaneous patients had fewer (median 1 versus 2) and smaller (median 2.5 versus 3.5 cm) metastases and less often underwent major (≥ three segments) hepatectomy (26.7% versus 61.3%, p < 0.05). Combined hospital stay was lower after simultaneous resections (median 8.5 versus 14 days, p < 0.0001). Mortality (1.0% versus 0.5%) and severe morbidity (14.1% versus 12.5%) were similar after simultaneous colorectal resection and minor hepatectomy compared with isolated minor hepatectomy (both p > 0.05). For major hepatectomy, simultaneous colorectal resection increased mortality (8.3% versus 1.4%, p < 0.05) and severe morbidity (36.1% versus 15.1%, p < 0.05). Combined severe morbidity after staged resections was lower compared to simultaneous resections (36.1% versus 17.6%, p = 0.05) for major hepatectomy but similar for minor hepatectomy (14.1% versus 10.5%, p > 0.05). Major hepatectomy independently predicted severe morbidity after simultaneous resections [hazard ratio (HR) = 3.4, p = 0.008]. Conclusions Simultaneous colorectal and minor hepatic resections are safe and should be performed for most patients with SCRLM. Due to increased risk of severe morbidity, caution should be exercised before performing simultaneous colorectal and major hepatic resections. en_US
dc.language.iso en en_US
dc.title Simultaneous Resections of Colorectal Cancer and Synchronous Liver Metastases en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle A Multi-institutional Analysis en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Gastrointestinal Oncology en_US
dc.journal.volume 14 en_US
dc.journal.issue 12 en_US
dc.article.pages 3481-3491 en_US
dc.keywords Simultaneous en_US
dc.keywords Colorectal cancer en_US
dc.keywords Hepatic metastases en_US
dc.keywords Hepatectomy en_US
dc.keywords Chemotherapy en_US
dc.keywords Resection en_US
dc.identifier.ctation Reddy, S. K., Pawlik, T. M., Zorzi, D., Gleisner, A. L., Ribero, D., Assumpcao, L., ... & Clary, B. M. (2007). Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis. Annals of surgical oncology, 14(12), 3481-3491. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://link.springer.com/article/10.1245/s10434-007-9522-5

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