Liver-Directed Surgery for Metastatic Squamous Cell Carcinoma to the Liver

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dc.contributor.author Pawlik, Timothy
dc.contributor.author Gleisner, Ana Luiza
dc.contributor.author Bauer, Todd
dc.contributor.author Reddy, Srinevas
dc.contributor.author Clary, Bryan
dc.contributor.author Martin, Robert
dc.contributor.author Scoggins, Charles
dc.contributor.author Tanabe, Kenneth
dc.contributor.author Michealson, James
dc.contributor.author Kooby, David
dc.contributor.author Staley, Charles
dc.contributor.author Schulick, Richard
dc.contributor.author Vauthey, Nicolas
dc.contributor.author Abdalla, Eddie
dc.contributor.author Curley, Steven
dc.contributor.author Choti, Micheal
dc.contributor.author Elias, Dominique
dc.date.accessioned 2015-11-16T09:29:48Z
dc.date.available 2015-11-16T09:29:48Z
dc.date.copyright 2007
dc.date.issued 2015-11-16
dc.identifier.issn 1068-9265 en_US
dc.identifier.uri http://hdl.handle.net/10725/2574
dc.description.abstract Background The role of hepatic resection for metastatic squamous cell carcinoma (SCC) remains unknown. The current study evaluates the role of hepatic resection in patients with metastatic SCC to the liver. Methods Between 1988 and 2006, 52 patients underwent hepatic resection of metastatic SCC at eight major cancer centers. Clinicopathologic factors were analyzed with regard to disease-free survival (DFS) and overall survival (OS). Results Primary SCC site was anal (n = 27), head/neck (n = 12), lung (n = 4), esophagus (n = 2), and other (n = 7). Treatment of primary SCC was chemotherapy ± radiotherapy alone (n = 29), chemotherapy ± radiotherapy + surgery (n = 15), or surgery alone (n = 8). Forty-seven patients underwent resection alone, 2 resection + radiofrequency ablation (RFA), and 3 RFA only. At last follow-up, 33 (63.5%) patients had recurred. The median time to recurrence was 9.8 months, and 5-year DFS was 18.6%. Factors associated with reduced DFS were liver tumor size > 5 cm (hazard ratio (HR) = 2.02) and positive surgical margin (HR = 2.33). The overall median survival after hepatic resection was 22.3 months and 5-year actuarial OS was 20.5%. Risk factors associated with worse overall survival included synchronous disease (HR = 4.09), hepatic metastasis > 5 cm (HR = 1.71) and positive surgical resection margin (HR = 1.83). Conclusions The majority of patients will recur following hepatic resection of SCC. Long-term survival, however, can be achieved following surgical resection of SCC liver metastasis, especially in patients who present with limited metachronous disease amenable to margin negative resection. en_US
dc.language.iso en en_US
dc.title Liver-Directed Surgery for Metastatic Squamous Cell Carcinoma to the Liver en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle Results of a Multi-Center Analysis en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Gastrointestinal Oncology en_US
dc.journal.volume 14 en_US
dc.journal.issue 10 en_US
dc.article.pages 2807-2816 en_US
dc.keywords Squamous cell carcinoma en_US
dc.keywords Hepatic resection en_US
dc.keywords Prognosis en_US
dc.identifier.doi http://dx.doi.org/10.1245/s10434-007-9467-8 en_US
dc.identifier.ctation Pawlik, T. M., Gleisner, A. L., Bauer, T. W., Adams, R. B., Reddy, S. K., Clary, B. M., ... & Elias, D. (2007). Liver-directed surgery for metastatic squamous cell carcinoma to the liver: results of a multi-center analysis. Annals of Surgical Oncology, 14(10), 2807-2816. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://link.springer.com/article/10.1245/s10434-007-9467-8

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