Comparison of CT Methods for Determining the Fat Content of the Liver

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dc.contributor.author Kodama, Yoshihisa
dc.contributor.author Ng, Chaan
dc.contributor.author Wu, Tsung-T
dc.contributor.author Ayers, Gregory
dc.contributor.author Curley, Steven
dc.contributor.author Abdalla, Eddie
dc.contributor.author Vauthey, Nicolas
dc.contributor.author Chamsangavej, Chulsip
dc.date.accessioned 2015-11-16T07:45:29Z
dc.date.available 2015-11-16T07:45:29Z
dc.date.copyright 2007
dc.date.issued 2015-11-16
dc.identifier.issn 0361-803X en_US
dc.identifier.uri http://hdl.handle.net/10725/2572
dc.description.abstract OBJECTIVE. The purpose of this study was to assess which of a number of methods of measuring attenuation on CT scans is best for prediction of hepatic fat content. MATERIALS AND METHODS. This retrospective study was approved by our institutional review board. Consecutively registered patients who underwent liver resection for metastatic disease formed the study group. Attenuation measurements were obtained from 12 regions of interest in the liver and three in the spleen on both unenhanced and portal phase contrast-enhanced preoperative hepatic CT images. Hepatic attenuation measurements were analyzed both with and without normalization with the spleen. Normalization included both differences and ratios between hepatic and splenic attenuation values. Pathologic fat content was graded semiquantitatively as a percentage of the nonneoplastic liver parenchyma of the resected specimen. Average attenuation values of the liver were compared with pathologic fat content, as were the differences and ratios between hepatic and splenic attenuation values. Linear regression analysis was conducted on a log-log scale. RESULTS. Data on 88 patients were analyzed. On unenhanced and contrast-enhanced CT images, all associations between pathologic fat content and attenuation measurements were significant (p < 0.0001). All series of R2 values for unenhanced CT scans were much higher than those for contrast-enhanced CT scans. The R2 values of liver-only measurement were higher than those of hepatic values normalized with splenic values on both unenhanced (0.646-0.649 > 0.523, 0.565) and contrast-enhanced (0.516 > 0.242, 0.344) CT. CONCLUSION. Measurement of attenuation of liver only on unenhanced CT scans is best for prediction of pathologic fat content. en_US
dc.language.iso en en_US
dc.title Comparison of CT Methods for Determining the Fat Content of the Liver en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal American Journal of Roentgenology en_US
dc.journal.volume 188 en_US
dc.journal.issue 5 en_US
dc.article.pages 1307-1312 en_US
dc.keywords CT en_US
dc.keywords Fat measurement en_US
dc.keywords Liver disease en_US
dc.identifier.doi http://dx.doi.org/10.2214/AJR.06.0992 en_US
dc.identifier.ctation Kodama, Y., Ng, C. S., Wu, T. T., Ayers, G. D., Curley, S. A., Abdalla, E. K., ... & Charnsangavej, C. (2007). Comparison of CT methods for determining the fat content of the liver. American Journal of Roentgenology, 188(5), 1307-1312. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://www.ajronline.org/doi/abs/10.2214/AJR.06.0992

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