Delayed Recovery after Pancreaticoduodenectomy

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dc.contributor.author Abdalla, Eddie
dc.contributor.author Aloia, Thomas
dc.contributor.author Lee, Jeffrey
dc.contributor.author Vauthey, Nicolas
dc.contributor.author Wolff, Robert
dc.contributor.author Varadhachary, Gauri
dc.contributor.author Abbruzzese, James
dc.contributor.author Crane, Christopher
dc.contributor.author Evans, Douglas
dc.contributor.author Pisters, Peter
dc.date.accessioned 2015-11-12T13:03:58Z
dc.date.available 2015-11-12T13:03:58Z
dc.date.copyright 2007
dc.date.issued 2015-11-12
dc.identifier.uri http://hdl.handle.net/10725/2553
dc.description.abstract Background Delayed recovery after pancreaticoduodenectomy (PD) is believed to preclude adjuvant therapy for approximately 30% of patients who undergo elective PD as initial treatment for pancreatic adenocarcinoma. This study reexamined the frequency of delayed recovery and assessed other factors associated with adjuvant therapy administration after PD at a high-volume center. Study Design Preoperative and perioperative variables were reviewed in a consecutive series of 85 patients with pancreatic adenocarcinoma undergoing PD without preoperative chemotherapy or radiotherapy from 1990 to 2004. Results Study groups included patients undergoing emergency PD (group 1, n = 13); elective PD with good preoperative Eastern Cooperative Oncology Group (ECOG) performance status (PS) (group 2, ECOG PS: 0 to 1, n = 63); and elective PD with marginal preoperative PS (group 3, ECOG PS: 2 to 3, n = 9). Delayed recovery of PS precluded adjuvant therapy in 23% of patients in group 1, 6% of patients in group 2, and 44% of patients in group 3 (p = 0.0001). Conclusions The impact of delayed recovery after PD on the delivery of adjuvant therapy depends on the urgency of surgery and the preoperative PS. For patients with good preoperative PS who undergo elective PD at a high-volume center, it is uncommon for delayed recovery to preclude delivery of adjuvant therapy. en_US
dc.language.iso en en_US
dc.title Delayed Recovery after Pancreaticoduodenectomy en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle A Major Factor Impairing the Delivery of Adjuvant Therapy? en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of the American College of Surgeons en_US
dc.journal.volume 204 en_US
dc.journal.issue 3 en_US
dc.article.pages 347-355 en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.jamcollsurg.2006.12.011 en_US
dc.identifier.ctation Aloia, T. E., Lee, J. E., Vauthey, J. N., Abdalla, E. K., Wolff, R. A., Varadhachary, G. R., ... & Pisters, P. W. (2007). Delayed recovery after pancreaticoduodenectomy: a major factor impairing the delivery of adjuvant therapy?. Journal of the American College of Surgeons, 204(3), 347-355. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S107275150601787X

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