Hepatic Resection for Metastatic Melanoma

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dc.contributor.author Abdalla, Eddie
dc.contributor.author Pawlik, Timothy
dc.contributor.author Zorzi, Daria
dc.contributor.author Clary, Bryan
dc.contributor.author Gershenwald, Jeffrey
dc.contributor.author Ross, Merrick
dc.contributor.author Aloia, Thomas
dc.contributor.author Curley, Steven
dc.contributor.author Camacho, Luis
dc.contributor.author Capussotti, Lorenzo
dc.contributor.author Elias, Dominique
dc.contributor.author Vauthey, Nicolas
dc.date.accessioned 2015-11-12T09:59:08Z
dc.date.available 2015-11-12T09:59:08Z
dc.date.copyright 2006
dc.date.issued 2015-11-12
dc.identifier.issn 1068-9265 en_US
dc.identifier.uri http://hdl.handle.net/10725/2546
dc.description.abstract Background Resection of melanoma metastatic to the liver remains controversial. We evaluated the efficacy of hepatic resection in patients with metastatic ocular and cutaneous melanoma and assessed factors that could affect survival after resection. Methods Forty patients with hepatic melanoma metastasis underwent resection at four major hepatobiliary centers. Clinicopathologic factors were evaluated with regard to recurrence and survival by using χ2 and log-rank tests. Results The primary tumor was ocular in 16 patients and cutaneous in 24. The median disease-free interval from the time of primary tumor treatment to hepatic metastasis was the same for both groups (ocular, 62.9 months; cutaneous, 63.1 months; P = .94). Most patients underwent either an extended hepatic resection (37.5%) or hemihepatectomy (22.5%). Twenty-six patients (65%) received perioperative systemic therapy. Thirty (75.0%) of 40 patients developed tumor recurrence. The median time to recurrence after hepatic resection was 8.3 months (ocular, 8.8 months; cutaneous, 4.7 months; P = .3). Patients with primary ocular melanoma were more likely to experience recurrence within the liver (53.3% vs. 17.4%; P = .015), whereas patients with a cutaneous primary tumor more often developed extrahepatic involvement. The 5-year survival rate for patients with a primary ocular melanoma was 20.5%, whereas there were no 5-year survivors for patients with cutaneous melanoma (P = .03). Conclusions Patterns of recurrence and prognosis after resection of hepatic melanoma metastasis differ depending on whether the primary melanoma is ocular or cutaneous. Resection should be performed as part of a multidisciplinary approach, because recurrence is common. en_US
dc.language.iso en en_US
dc.title Hepatic Resection for Metastatic Melanoma en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle Distinct Patterns of Recurrence and Prognosis for Ocular Versus Cutaneous Disease en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Annals of Surgical Oncology en_US
dc.journal.volume 13 en_US
dc.journal.issue 5 en_US
dc.article.pages 712-720 en_US
dc.keywords Melanoma en_US
dc.keywords Ocular en_US
dc.keywords Cutaneous en_US
dc.keywords Liver en_US
dc.keywords Resection en_US
dc.keywords Outcome en_US
dc.identifier.doi http://dx.doi.org/10.1245/ASO.2006.01.016 en_US
dc.identifier.ctation Pawlik, T. M., Zorzi, D., Abdalla, E. K., Clary, B. M., Gershenwald, J. E., Ross, M. I., ... & Vauthey, J. N. (2006). Hepatic resection for metastatic melanoma: distinct patterns of recurrence and prognosis for ocular versus cutaneous disease. Annals of surgical oncology, 13(5), 712-720. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://link.springer.com/article/10.1245/ASO.2006.01.016

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