Transhepatic Ipsilateral Right Portal Vein Embolization Extended to Segment IV

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dc.contributor.author Madoff, David
dc.contributor.author Abdalla, Eddie
dc.contributor.author Gupta, Sanjay
dc.contributor.author Morris, Jeffrey
dc.contributor.author Denys, Alban
dc.contributor.author Wallace, Micheal
dc.contributor.author Morello, Frank
dc.contributor.author Ahrar, Kamran
dc.contributor.author Murthy, Ravi
dc.contributor.author Hicks, Marshall
dc.contributor.author Vauthey, Nicolas
dc.date.accessioned 2015-11-11T11:29:51Z
dc.date.available 2015-11-11T11:29:51Z
dc.date.copyright 2005
dc.date.issued 2015-11-11
dc.identifier.issn 1051-0443 en_US
dc.identifier.uri http://hdl.handle.net/10725/2532
dc.description.abstract PURPOSE To analyze outcomes after right portal vein embolization extended to segment IV (right PVE + IV) before extended right hepatectomy, including liver hypertrophy, resection rates, and complications after embolization and resection, and to assess differences in outcomes with two different particulate embolic agents. MATERIALS AND METHODS Between 1998 and 2004, transhepatic ipsilateral right PVE + IV with particles and coils was performed in 44 patients with malignant hepatobiliary disease, including metastases (n = 24), biliary cancer (n = 14), and hepatocellular carcinoma (n = 6). Right PVE + IV was considered if the future liver remnant (FLR; segments II/III with or without I) was less than 25% of the total estimated liver volume (TELV). Tris-acryl microspheres (100–700 μm; n = 21) or polyvinyl alcohol (PVA) particles (355–1,000 μm; n = 23) were administered in a stepwise fashion. Smaller particles were used to occlude distal branches, followed by larger particles to occlude proximal branches until near-complete stasis. Coils were then placed in secondary portal branches. Computed tomographic volumetry was performed before and 3–4 weeks after right PVE + IV to assess FLR hypertrophy. Liver volumes and postembolization and postoperative outcomes were measured. RESULTS After right PVE + IV with PVA particles, FLR volume increased 45.5% ± 40.9% and FLR/TELV ratio increased 6.9% ± 5.6%. After right PVE + IV with tris-acryl microspheres, FLR volume increased 69.0% ± 30.7% and FLR/TELV ratio increased 9.7% ± 3.3%. Differences in FLR volume (P = .0011), FLR/TELV ratio (P = .027), and resection rates (P = .02) were statistically significant. Seventy-one percent of patients underwent extended right hepatectomy (86% after receiving tris-acryl microspheres, 57% after receiving PVA). Thirteen patients (29%) did not undergo resection (extrahepatic spread [n = 9], inadequate hypertrophy [n = 3], other reasons [n = 1]). No patient developed postembolization syndrome or progressive liver insufficiency after embolization or resection. One death after resection occurred as a result of sepsis and hemorrhage. Median hospital stays were 1 day after right PVE + IV and 7 days after resection. CONCLUSION Transhepatic ipsilateral right PVE + IV with use of particles and coils is a safe, effective method for inducing contralateral hypertrophy before extended right hepatectomy. Embolization with small spherical particles provides improved hypertrophy and resection rates compared with larger, nonspherical particles. en_US
dc.language.iso en en_US
dc.title Transhepatic Ipsilateral Right Portal Vein Embolization Extended to Segment IV en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle Improving Hypertrophy and Resection Outcomes with Spherical Particles and Coils en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of vascular and interventional radiology en_US
dc.journal.volume 16 en_US
dc.journal.issue 2 en_US
dc.article.pages 215-225 en_US
dc.identifier.doi http://dx.doi.org/10.1097/01.RVI.0000147067.79223.85 en_US
dc.identifier.ctation Madoff, D. C., Abdalla, E. K., Gupta, S., Wu, T. T., Morris, J. S., Denys, A., ... & Vauthey, J. N. (2005). Transhepatic ipsilateral right portal vein embolization extended to segment IV: improving hypertrophy and resection outcomes with spherical particles and coils. Journal of vascular and interventional radiology, 16(2), 215-225. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S1051044307605508

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