Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients

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dc.contributor.author Curley, Steven
dc.contributor.author Marra, Paolo
dc.contributor.author Beaty, Karen
dc.contributor.author Vauthey, Nicolas
dc.contributor.author Abdalla, Eddie
dc.contributor.author Scaife, Courtney
dc.contributor.author Raut, Chan
dc.contributor.author Wolff, Robert
dc.contributor.author Choi, Haesun
dc.contributor.author Loyer, Evelyne
dc.contributor.author Vallone, Paolo
dc.contributor.author Fiore, Francesco
dc.contributor.author Scordino, Fabrizio
dc.contributor.author Di Rosa, Vincenzo
dc.contributor.author Orlando, Raffaele
dc.contributor.author Pignata, Sandro
dc.contributor.author Daniele, Bruno
dc.contributor.author Izzo, Francesco
dc.date.accessioned 2015-11-10T15:20:40Z
dc.date.available 2015-11-10T15:20:40Z
dc.date.copyright 2004
dc.date.issued 2015-11-10
dc.identifier.issn 0003-4932 en_US
dc.identifier.uri http://hdl.handle.net/10725/2523
dc.description.abstract Background: Radiofrequency ablation (RFA) has become a common treatment of patients with unresectable primary and secondary hepatic malignancies. We performed this prospective analysis to determine early (within 30 days) and late (more than 30 days after) complication rates associated with hepatic tumor RFA. Methods: All patients treated between January 1, 1996 and June 30, 2002 with RFA for hepatic malignancies were entered into a prospective database. Patients were evaluated during RFA treatment, throughout the immediate post RFA course, and then every 3 months after RFA to assess for the development of treatment-related complications. Results: A total of 608 patients, 345 men (56.7%) and 263 women (43.3%), with a median age of 58 years (range 18–85 years) underwent RFA of 1225 malignant liver tumors. Open intraoperative RFA was performed in 382 patients (62.8%), while percutaneous RFA was performed in 226 (37.2%). The treatment-related mortality rate was 0.5%. Early complications developed in 43 patients (7.1%). Early complications were more likely to occur in patients treated with open RFA (33 [8.6%] of 382 patients) compared with percutaneous RFA (10 [4.4%] 226 patients, P < 0.01), and in patients with cirrhosis (25 [12.9%] complications in 194 patients) compared with noncirrhotic patients (31 [7.5%] complications in 414 patients, P < 0.05). Late complications arose in 15 patients (2.4%) with no difference in incidence between open and percutaneous RFA treatment. The combined overall early and late complication rate was 9.5%. Conclusions: Hepatic tumor RFA can be performed with low mortality and morbidity rates. Though relatively rare, late complications can develop and physicians performing hepatic RFA must be cognizant of these delayed treatment-related problems. en_US
dc.language.iso en en_US
dc.title Early and Late Complications After Radiofrequency Ablation of Malignant Liver Tumors in 608 Patients en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Annals of surgery en_US
dc.journal.volume 239 en_US
dc.journal.issue 4 en_US
dc.article.pages 450–458 en_US
dc.identifier.doi http://dx.doi.org/10.1097/01.sla.0000118373.31781.f2 en_US
dc.identifier.ctation Curley, S. A., Marra, P., Beaty, K., Ellis, L. M., Vauthey, J. N., Abdalla, E. K., ... & Izzo, F. (2004). Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients. Annals of surgery, 239(4), 450. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://link.springer.com/article/10.1007%2FBF02524164?LI=true

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