Surgical treatment of colorectal cancer metastasis

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dc.contributor.author Abdalla, Eddie
dc.contributor.author Izzo, Francesco
dc.contributor.author Curley, Steven
dc.contributor.author Vauthey, Nicolas
dc.date.accessioned 2015-11-10T15:06:58Z
dc.date.available 2015-11-10T15:06:58Z
dc.date.copyright 2004
dc.date.issued 2015-11-10
dc.identifier.issn 0167-7659 en_US
dc.identifier.uri http://hdl.handle.net/10725/2522
dc.description.abstract Colorectal cancer is one of the most common solid tumors affecting people around the world. A significant proportion of patients with colorectal cancer will develop or will present with liver metastases. In some of these patients, the liver is the only site of metastatic disease. Thus, surgical treatment approaches are an appropriate and important treatment option in patients with liver-only colorectal cancer metastases. Resection of colorectal cancer liver metastases can produce long-term survival in selected patients, but the efficacy of liver resection as a solitary treatment is limited by two factors. First, a minority of patients with liver metastases have resectable disease. Second, the majority of patients who undergo successful liver resection for colorectal cancer metastases develop recurrent disease in the liver, extrahepatic sites, or both. In this paper, in addition to the results of liver resection for colorectal cancer metastases, we will review the results of thermal ablation. Each of these surgical treatment modalities can produce long-term survival in a subset of patients with liver-only colorectal cancer metastases, whereas administration of systemic or regional chemotherapy rarely results in long-term survival in these patients. While surgical treatments provide the best chance for long-term survival or, in some cases, the best palliation in patients with colorectal cancer liver metastases, it is clear that further improvements in patient outcome will require multimodality therapy regimens. Modern surgical treatment of colorectal liver metastases can be performed safely with low mortality and transfusion rates, and surgical treatment should be considered in patients with disease confined to their liver. en_US
dc.language.iso en en_US
dc.title Surgical treatment of colorectal cancer metastasis en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Cancer and Metastasis Reviews en_US
dc.journal.volume 23 en_US
dc.journal.issue 1 en_US
dc.article.pages 165-182 en_US
dc.keywords Colorectal cancer en_US
dc.keywords Liver metastasis en_US
dc.keywords Surgery en_US
dc.identifier.doi http://dx.doi.org/10.1023/A:1025875332255 en_US
dc.identifier.ctation Curley, S. A., Izzo, F., Abdalla, E., & Vauthey, J. N. (2004). Surgical treatment of colorectal cancer metastasis. Cancer and metastasis reviews, 23(1-2), 165-182. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://link.springer.com/article/10.1023/A:1025875332255

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