Staging and preoperative evaluation of upper gastrointestinal malignancies

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dc.contributor.author Abdalla, Eddie
dc.contributor.author Pisters, Peter
dc.date.accessioned 2015-11-10T14:50:37Z
dc.date.available 2015-11-10T14:50:37Z
dc.date.copyright 2004
dc.date.issued 2015-11-10
dc.identifier.issn 0093-7754 en_US
dc.identifier.uri http://hdl.handle.net/10725/2520
dc.description.abstract Esophageal and gastric cancers are distinct carcinomas of the upper gastrointestinal tract, although the distinction between them becomes less clear at the gastroesophageal junction (GEJ). Increasingly accurate staging is possible based on newer radiographic and surgical techniques such as positron emission tomography (PET), laparoscopy and thoracoscopy, laparoscopic ultrasound, and endoscopic ultrasound (EUS). For both cancer types, tumor classification is determined by depth of penetration of the primary tumor into the gastric or esophageal wall. For esophageal cancer, primary tumor anatomic position-upper, mid, and lower esophagus-is used to define the local nodal basin. Metastases in nodes outside the local basin are considered to be distant (M) rather than regional (N). In gastric cancer, the region of nodal metastasis has been abandoned in favor of the number of lymph nodes containing metastasis, which predicts outcome more accurately—patients with more than 15 positive lymph nodes have an outcome comparable to those with M disease. Increasing consideration is being given to the subclassification of tumors near the GEJ into types based on anatomical position, although this staging scheme (“Full-size image (<1 K)denocarcinoma of the Full-size image (<1 K)sophagoFull-size image (<1 K)astric junction” or AEG type) has not yet been universally adopted. We review the current pathologic staging systems for esophageal and gastric cancers, the clinical staging approaches for these diseases, and the controversy surrounding classification of tumors of the GEJ. en_US
dc.language.iso en en_US
dc.title Staging and preoperative evaluation of upper gastrointestinal malignancies en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Seminars in Oncology en_US
dc.journal.volume 31 en_US
dc.journal.issue 4 en_US
dc.article.pages 513-529 en_US
dc.identifier.doi http://dx.doi.org/10.1053/j.seminoncol.2004.04.014 en_US
dc.identifier.ctation Abdalla, E. K., & Pisters, P. W. (2004, August). Staging and preoperative evaluation of upper gastrointestinal malignancies. In Seminars in oncology (Vol. 31, No. 4, pp. 513-529). WB Saunders. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0093775404002350

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