Resection Prior to Liver Transplantation for Hepatocellular Carcinoma

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dc.contributor.author Belghiti, Jacques
dc.contributor.author Cortes, Alexandre
dc.contributor.author Abdalla, Eddie
dc.contributor.author Regimbeau, Jean-Marc
dc.contributor.author Prakash, Kurumboor
dc.contributor.author Durand, Francois
dc.contributor.author Sommacale, Daniele
dc.contributor.author Dondero, Federica
dc.contributor.author Lesurtel, Mickeal
dc.contributor.author Sauvanet, Alain
dc.contributor.author Farges, Olivier
dc.contributor.author Kianmanesh, Reza
dc.date.accessioned 2015-11-10T12:43:55Z
dc.date.available 2015-11-10T12:43:55Z
dc.date.copyright 2003
dc.date.issued 2015-11-10
dc.identifier.issn 0003-4932 en_US
dc.identifier.uri http://hdl.handle.net/10725/2514
dc.description.abstract Objective: To evaluate the feasibility and postoperative course of liver transplantation (LT) in cirrhotic patients who underwent liver resection prior to LT for HCC. Summary Background Data: Although LT provides longer survival than liver resection for treatment of small HCCs, donor shortage and long LT wait time may argue against LT. The feasibility and survival following LT after hepatic resection have not been previously examined. Methods: Between 1991 and 2001, among 107 patients who underwent LT for HCC, 88 met Mazzafero’s criteria upon pathologic analysis of the explant. Of these, 70 underwent primary liver transplantation (PLT) and 18 liver resection prior to secondary liver transplantation (SLT) for recurrence (n = 11), deterioration of liver function (n = 4), or high risk for recurrence (n = 3). Perioperative and postoperative factors and long-term survival were compared. Results: Comparison of PLT and SLT groups at the time of LT revealed similar median age (53 vs. 55 years), sex, and etiology of liver disease (alcohol/viral B/C/other). In the SLT group, the mean time between liver resection and listing for LT was 20 months (range 1–84 months). Overall time on LT waiting list of the two groups was similar (3 vs. 5 months). Pathologic analysis after LT revealed similar tumor size (2.2 vs. 2.3 cm) and number (1.6 vs. 1.7). Perioperative and postoperative courses were not different in terms of operative time (551 vs. 530 minutes), blood loss (1191 vs. 1282 mL), transfusion (3 vs. 2 units), ICU (9 vs. 10 days) or hospital stay (32 vs. 31 days), morbidity (51% vs. 56%) or 30-day mortality (5.7% vs. 5.6%). During a median follow-up of 32 months (3 to 158 months), 3 patients recurred after PLT and one after SLT. After transplantation, 3- and 5-year overall survivals were not different between groups (82 vs. 82% and 59 vs. 61%). Conclusions: In selected patients, liver resection prior to transplantation does not increase the morbidity or impair long-term survival following LT. Therefore, liver resection prior to transplantation can be integrated in the treatment strategy for HCC. en_US
dc.language.iso en en_US
dc.title Resection Prior to Liver Transplantation for Hepatocellular Carcinoma en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.journal.volume 238 en_US
dc.journal.issue 6 en_US
dc.article.pages 885-893 en_US
dc.identifier.doi http://dx.doi.org/10.1097/01.sla.0000098621.74851.65 en_US
dc.identifier.ctation Belghiti, J., Cortes, A., Abdalla, E. K., Régimbeau, J. M., Prakash, K., Durand, F., ... & Kianmanesh, R. (2003). Resection prior to liver transplantation for hepatocellular carcinoma. Annals of surgery, 238(6), 885. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://journals.lww.com/annalsofsurgery/Abstract/2003/12000/Resection_Prior_to_Liver_Transplantation_for.12.aspx

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