Recent advances in the treatment and outcome of locally advanced rectal cancer

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dc.contributor.author Abdalla, Eddie
dc.contributor.author Vauthey, Nicolas
dc.contributor.author Marsh, Robert
dc.contributor.author Zlotecki, Robert
dc.contributor.author Solorzano, Carmen
dc.contributor.author Bray, Elizabeth
dc.contributor.author Freeman, Mark
dc.contributor.author Lauwers, Gregory
dc.contributor.author Kubilis, Paul
dc.contributor.author Mendenhall, William
dc.contributor.author Copeland III, Edward
dc.date.accessioned 2015-11-09T14:10:01Z
dc.date.available 2015-11-09T14:10:01Z
dc.date.copyright 1999
dc.date.issued 2015-11-09
dc.identifier.issn 0003-4932 en_US
dc.identifier.uri http://hdl.handle.net/10725/2503
dc.description.abstract Objective To compare the outcomes of treatment of locally advanced rectal cancer of the early era (1975–1990) with those of the late era (1991–1997). Background Preoperative therapy has been used in locally advanced rectal cancer to preserve sphincter function, decrease local recurrence, and improve survival. At the University of Florida, preoperative radiation has been used since 1975, and it was combined with chemotherapy beginning in 1991. Methods The records of 328 patients who underwent preoperative radiation or chemoradiation followed by complete resection for locally advanced rectal cancer defined as tethered, annular, or fixed tumors were reviewed. The clinicopathologic characteristics, adjuvant treatment administered, surgical procedures performed, and local recurrence-free and overall survival rates were analyzed. Results There were 219 patients in the early era and 109 in the late era. No significant differences were seen in patients (age, gender, race) or tumor characteristics (mean distance from the anal verge, annularity, fixation). Preoperative radiation regimens were radiobiologically comparable. No patient in the early era received preoperative chemotherapy, compared with 64 in the late era. Of those receiving any pre- or postoperative chemotherapy, three patients received chemotherapy in the early era, compared with 76 in the late era. Sphincter-preserving procedures increased from 13% in the early era to 52% in the late era. Pathologic downstaging for depth of invasion increased from 42% to 58%, but lymph node negativity remained similar. The 1-, 3-, and 5-year local recurrence-free survival rates were comparable. However, in the late era, 1-, 3-, and 5-year overall survival rates improved significantly compared with those of the early era, and also compared with each of the preceding 5-year intervals. en_US
dc.language.iso en en_US
dc.title Recent advances in the treatment and outcome of locally advanced rectal cancer en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201100945 en_US
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Recent advances in the treatment and outcome of locally advanced rectal cancer en_US
dc.journal.volume 229 en_US
dc.journal.issue 5 en_US
dc.article.pages 745-754 en_US
dc.identifier.ctation Vauthey, J. N., Marsh, R. D. W., Zlotecki, R. A., Abdalla, E. K., Solorzano, C. C., Bray, E. J., ... & Copeland III, E. M. (1999). Recent advances in the treatment and outcome of locally advanced rectal cancer. Annals of surgery, 229(5), 745. en_US
dc.author.email eddie.abdalla@lau.edu.lb
dc.identifier.url http://journals.lww.com/annalsofsurgery/Abstract/1999/05000/Recent_Advances_in_the_Treatment_and_Outcome_of.18.aspx

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