Rho GTPases in primary brain tumor malignancy and invasion

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dc.contributor.author Khalil, Bassem D.
dc.contributor.author El-Sibai, Mirvat
dc.date.accessioned 2015-11-04T10:54:17Z
dc.date.available 2015-11-04T10:54:17Z
dc.date.copyright 2012
dc.date.issued 2015-11-04
dc.identifier.issn 0167-594X en_US
dc.identifier.uri http://hdl.handle.net/10725/2432
dc.description.abstract Gliomas are the most common type of malignant primary brain tumor in humans, accounting for 80 % of malignant cases. Expression and activity of Rho GTPases, which coordinate several cellular processes including cellcycle progression and cell migration, are commonly altered in many types of primary brain tumor. Here we review the suggested effects of deregulated Rho GTPase signaling on brain tumor malignancy, highlighting the controversy in the field. For instance, whereas expression of RhoA and RhoB has been found to be significantly reduced in astrocytic tumors, other studies have reported Rho-dependent LPAinduced migration in glioma cells. Moreover, whereas the Rac1 expression level has been found to be reduced in astrocytic tumor, it was overexpressed and induced invasion in medulloblastoma tumors. In addition to the Rho GTPases themselves, several of their downstream effectors (including ROCK, mDia, and N-WASP) and upstream regulators (including GEFs, GAPs, PI3K, and PTEN) have also been implicated in primary brain tumors. en_US
dc.language.iso en en_US
dc.title Rho GTPases in primary brain tumor malignancy and invasion en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 200703859 en_US
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Neuro-Oncology en_US
dc.journal.volume 108 en_US
dc.article.pages 333-339 en_US
dc.keywords Brain tumors en_US
dc.keywords Rho-GTPases en_US
dc.keywords Rho en_US
dc.keywords Rac en_US
dc.keywords Cdc42 en_US
dc.identifier.doi http://dx.doi.org/10.1007/s11060-012-0866-8 en_US
dc.identifier.ctation Khalil, B. D., & El-Sibai, M. (2012). Rho GTPases in primary brain tumor malignancy and invasion. Journal of neuro-oncology, 108(3), 333-339. en_US
dc.author.email mirvat.elsibai@lau.edu.lb
dc.identifier.url http://link.springer.com/article/10.1007/s11060-012-0866-8
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US

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