DLC2/StarD13 plays a role of a tumor suppressor in astrocytoma

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dc.contributor.author El-Sitt, Sally
dc.contributor.author Khalil, Bassem D.
dc.contributor.author Hanna, Samer
dc.contributor.author El-Sabban, Marwan
dc.contributor.author Fakhreddine, Najla
dc.contributor.author El-Sibai, Mirvat
dc.date.accessioned 2015-11-04T10:35:05Z
dc.date.available 2015-11-04T10:35:05Z
dc.date.copyright 2012
dc.date.issued 2015-11-04
dc.identifier.issn 1021-335X en_US
dc.identifier.uri http://hdl.handle.net/10725/2431
dc.description.abstract Astrocytomas are tumors occurring in young adult-hood. Astrocytic tumors can be classified into four grades according to histologic features: grades I, II, III and grade IV. Malignant tumors, those of grades III and IV, are characterized by uncontrolled proliferation, which is known to be regulated by the family of Rho GTPases. StarD13, a GAP for Rho GTPases, has been described as a tumor suppressor in hepatocellular carcinoma. In the present study, IHC analysis on grades I-IV brain tissues from patients showed StarD13 to be overexpressed in grades III and IV astrocytoma tumors when compared to grades I and II. However, when we mined the REMBRANDT data, we found that the mRNA levels of StarD13 are indeed higher in the higher grades but much lower than the normal tissues. Knocking down StarD13 using siRNA led to a decrease in cell death and an increase in cell viability, proving that StarD13 is indeed a tumor suppressor in astrocytomas. This was found to be mainly through cell cycle arrest independently of apoptosis. Finally, we detected an increase in p-ERK in StarD13 knockdown cells, uncovering a potential link between Rho GTPases and ERK activation. en_US
dc.language.iso en en_US
dc.title DLC2/StarD13 plays a role of a tumor suppressor in astrocytoma en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 200703859 en_US
dc.author.woa N/A en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Oncology Reports en_US
dc.journal.volume 28 en_US
dc.journal.issue 2 en_US
dc.article.pages 511-518 en_US
dc.keywords Tumor en_US
dc.keywords Nervous system diseases en_US
dc.keywords Central nervous system disease en_US
dc.keywords Glioma en_US
dc.keywords Cancerology en_US
dc.keywords Tumor suppressor gene en_US
dc.keywords Astrocytoma en_US
dc.identifier.doi http://dx.doi.org/10.3892/or.2012.1819 en_US
dc.identifier.ctation El-Sitt, S., Khalil, B. D., Hanna, S., El-Sabban, M., Fakhreddine, N., & El-Sibai, M. (2012). DLC2/StarD13 plays a role of a tumor suppressor in astrocytoma. Oncology reports, 28(2), 511-518. en_US
dc.author.email mirvat.elsibai@lau.edu.lb
dc.identifier.url https://www.spandidos-publications.com/10.3892/or.2012.1819
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US

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