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Atherosclerosis Initiation Modeled as an Inflammatory Process

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dc.contributor.author El Khatib, N.
dc.contributor.author Genieys, S.
dc.contributor.author Volpert, V.
dc.date.accessioned 2015-10-28T11:50:39Z
dc.date.available 2015-10-28T11:50:39Z
dc.date.copyright 2007
dc.date.issued 2015-10-28
dc.identifier.issn 0973-5348 en_US
dc.identifier.uri http://hdl.handle.net/10725/2366
dc.description.abstract In this work we study the inflammatory process resulting in the development of atherosclerosis. We develop a one- and two-dimensional models based on reaction-diffusion systems to describe the set up of a chronic inflammatory response in the intima of an artery vessel wall. The concentration of the oxidized low density lipoproteins (ox-LDL) in the intima is the critical parameter of the model. Low ox-LDL concentrations do not lead to a chronic inflammatory reaction. Intermediate ox-LDL concentrations correspond to a bistable system and can lead to a travelling wave propagation corresponding to a chronic inflammatory reaction. In this case the disease development depends on the initial condition. If the concentration of monocytes in the intima is sufficiently high, which can be caused by an inflammation related to other factors, then the development of atherosclerosis can start. Otherwise, the system returns to the stable disease free equilibrium. High ox-LDL concentrations correspond to a monostable system and even a small perturbation of the non inflammatory case leads to a travelling wave propagation which corresponds to a chronic inflammatory response. en_US
dc.language.iso en en_US
dc.title Atherosclerosis Initiation Modeled as an Inflammatory Process en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201104930 en_US
dc.author.woa N/A en_US
dc.author.department Computer Science and Mathematics en_US
dc.description.embargo N/A en_US
dc.relation.journal Mathematical Modelling of Natural Phenomena en_US
dc.journal.volume 2 en_US
dc.journal.issue 2 en_US
dc.article.pages 126-141 en_US
dc.keywords Atherosclerosis en_US
dc.keywords Mathematical modelling en_US
dc.keywords Travelling waves en_US
dc.identifier.doi http://dx.doi.org/10.1051/mmnp:2008022 en_US
dc.identifier.ctation El Khatib, N., Genieys, S., & Volpert, V. (2007). Atherosclerosis initiation modeled as an inflammatory process. Mathematical Modelling of Natural Phenomena, 2(02), 126-141. en_US
dc.author.email nader.elkhatib@lau.edu.lb
dc.identifier.url http://www.mmnp-journal.org/articles/mmnp/abs/2007/02/mmnp2007208/mmnp2007208.html


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