Non-Newtonian Effects in a Fluid-Structure Interaction Model for Atherosclerosis

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dc.contributor.author El Khatib, N.
dc.contributor.author Génieys, S.
dc.contributor.author Zine, A. M.
dc.contributor.author Volpert, V.
dc.date.accessioned 2015-10-27T13:12:34Z
dc.date.available 2015-10-27T13:12:34Z
dc.date.copyright 2009-01
dc.date.issued 2016-05-09
dc.identifier.issn 0324-8313 en_US
dc.identifier.uri http://hdl.handle.net/10725/2356
dc.description.abstract The inflammatory process of atherosclerosis leads to the formation of an atheroma plaque in the blood vessel. The interaction between the blood and the plaque may have dangerous consequences such as the rupture of the plaque. This rupture exposes tissue factors to the blood flow, leading to the formation of a clot that might result in a heart attack or an ischemic stroke. The blood-plaque interaction may also produce recirculations downstream of the plaque, and these recirculations enhance the risk of clot formation. In this paper we study the blood-plaque interaction using a fluid-structure interaction model. The atheroma plaque is composed of a lipid pool and a fibrous cap and both are modeled as hyperelastic materials. The blood is supposed to be a non-Newtonian fluid with a variable viscosity modeled by the Carreau law. The parameters used in our simulations are taken from experimental data. We investigate the non-Newtonian effects on the recirculations downstream of the atheroma plaque and on the stress over the plaque. The simulations show that the Newtonian model significantly overestimates the recirculations in comparison with the non-Newtonian model. They also show that the Newtonian model slightly underestimates the stress over the plaque for usual shear rates, but that this underestimation can become significant for low shear rates. en_US
dc.language.iso en en_US
dc.title Non-Newtonian Effects in a Fluid-Structure Interaction Model for Atherosclerosis en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201104930 en_US
dc.author.woa N/A en_US
dc.author.department Computer Science and Mathematics en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Technical Physics en_US
dc.journal.volume 50 en_US
dc.journal.issue 1 en_US
dc.article.pages 55-64 en_US
dc.keywords Cardiovascular disease en_US
dc.keywords Numerical simulation en_US
dc.keywords Modeling en_US
dc.keywords Hemodynamics en_US
dc.keywords Blood vessel en_US
dc.keywords Atherosclerosis en_US
dc.keywords Non Newtonian fluid en_US
dc.keywords Blood flow en_US
dc.keywords Fluid structure interaction en_US
dc.identifier.ctation El Khatib, N., Génieys, S., Zine, A. M., & Volpert, V. (2009). Non-Newtonian effects in a fluid-structure interaction model for atherosclerosis. J. Tech. Phys, 1(50), 55-64. en_US
dc.author.email nader.elkhatib@lau.edu.lb
dc.identifier.url https://www.researchgate.net/profile/V_Volpert/publication/240305368_Non-Newtonian_effects_in_a_fluid-structure_interaction_model_for_atherosclerosis/links/54ccb6200cf29ca810f575a1.pdf

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