Human osteoblast-like cells express aromatase immunoreactivity

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dc.contributor.author Roa-Pena, Lucia
dc.contributor.author Zreik, Tony
dc.contributor.author Harada, Nobuhiro
dc.contributor.author Spelsberg, Thomas
dc.contributor.author Riggs, Lawrence
dc.contributor.author Naftolin, Frederick
dc.date.accessioned 2015-10-07T12:08:20Z
dc.date.available 2015-10-07T12:08:20Z
dc.date.copyright 1994
dc.date.issued 2015-10-07
dc.identifier.issn 1072-3714 en_US
dc.identifier.uri http://hdl.handle.net/10725/2277
dc.description.abstract The main source of estrogen after menopause is the peripheral aromatization of adrenal androgens. Estrogen synthetase (aromatase) has been described in several tissues including placenta, ovary, testis, brain, and adipose tissue. The possibility that bone cells themselves could be a local source of estrogen production has been raised in previous studies that reported the presence of aromatase activity in crushed rat mandible and human bone cells. To determine the presence of aromatase in bone cells, cultured male and female human osteoblast-like cells were immunostained with a specific antiserum generated against human aromatase. Aromatase-immunopositive granules were found throughout the entire cytoplasm in all cultures. The morphological demonstration of immunoreactive aromatase in bone cells indicates that bone may be a site of extragonadal aromatization in both sexes. These findings open new possibilities for understanding the mechanisms of bone metabolism, the development of peak bone mass, sex differences in bone mass, and issues regarding the role of sex steroids in bone maintenance and repair. en_US
dc.language.iso en en_US
dc.title Human osteoblast-like cells express aromatase immunoreactivity en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 200802707
dc.author.woa N/A en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Menopause en_US
dc.journal.volume 1 en_US
dc.journal.issue 2 en_US
dc.article.pages 73-78 en_US
dc.identifier.ctation Roa-Peña, L., Zreik, T., Harada, N., Spelsberg, T. C., Riggs, B. L., & Naftolin, F. (1994). Human Osteoblast-Like Cells Express Aromatase Immunoreactivity. Menopause, 1(2), 73-78. en_US
dc.author.email tgzreik@lau.edu.lb
dc.identifier.url http://journals.lww.com/menopausejournal/Abstract/1994/00120/Human_Osteoblast_Like_Cells_Express_Aromatase.3.aspx

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